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Association Between Improved Mobility and Distal Health Outcomes.
Shuman V, Coyle PC, Perera S, Van Swearingen JM, Albert SM, Brach JS. Shuman V, et al. J Gerontol A Biol Sci Med Sci. 2020 Nov 13;75(12):2412-2417. doi: 10.1093/gerona/glaa086. J Gerontol A Biol Sci Med Sci. 2020. PMID: 32270185 Free PMC article. Clinical Trial.
Incident rate ratios (IRRs) were calculated to quantify incidence of adverse outcomes with respect to mobility performance change. RESULTS: Each 0.05 m/s increase in gait speed resulted in an 11% reduction in falls (IRR = 0.89; 95% confidence interval [CI], 0.84-0.94; p …
Incident rate ratios (IRRs) were calculated to quantify incidence of adverse outcomes with respect to mobility performance change. RESULTS: …
Methanediol from cloud-processed formaldehyde is only a minor source of atmospheric formic acid.
Nguyen TL, Peeters J, Müller JF, Perera A, Bross DH, Ruscic B, Stanton JF. Nguyen TL, et al. Proc Natl Acad Sci U S A. 2023 Nov 28;120(48):e2304650120. doi: 10.1073/pnas.2304650120. Epub 2023 Nov 21. Proc Natl Acad Sci U S A. 2023. PMID: 37988470
High-level accuracy coupled cluster calculations in combination with E,J-resolved two-dimensional master equation analyses yield k(1) = (2.4 0.5) 10(-12) cm(3) s(-1) for relevant atmospheric conditions (T = 260-310 K and P = 0-1 atm). We attribute this significant discrepa …
High-level accuracy coupled cluster calculations in combination with E,J-resolved two-dimensional master equation analyses yield k(1) = (2.4 …
Gait Speed Predicts Incident Disability: A Pooled Analysis.
Perera S, Patel KV, Rosano C, Rubin SM, Satterfield S, Harris T, Ensrud K, Orwoll E, Lee CG, Chandler JM, Newman AB, Cauley JA, Guralnik JM, Ferrucci L, Studenski SA. Perera S, et al. J Gerontol A Biol Sci Med Sci. 2016 Jan;71(1):63-71. doi: 10.1093/gerona/glv126. Epub 2015 Aug 22. J Gerontol A Biol Sci Med Sci. 2016. PMID: 26297942 Free PMC article.
RESULTS: Participants with faster baseline gait had lower rates of incident disability. In subgroups (defined by 0.2 m/s-wide intervals from <0.4 to 1.4 m/s) with increasingly greater gait speed, 3-year rates of bathing or dressing dependence trended from 10% to …
RESULTS: Participants with faster baseline gait had lower rates of incident disability. In subgroups (defined by 0.2 m/s-wide interva …
A randomized trial of two forms of therapeutic activity to improve walking: effect on the energy cost of walking.
VanSwearingen JM, Perera S, Brach JS, Cham R, Rosano C, Studenski SA. VanSwearingen JM, et al. J Gerontol A Biol Sci Med Sci. 2009 Nov;64(11):1190-8. doi: 10.1093/gerona/glp098. Epub 2009 Jul 30. J Gerontol A Biol Sci Med Sci. 2009. PMID: 19643842 Free PMC article. Clinical Trial.
RESULTS: Of 50 participants (mean age, 77.2 +/- 5.5 years, 65% women), 47 completed the study. Baseline gait speed was 0.85 +/- 0.13 m/s and energy cost of walking was 0.30 +/- 0.10 mL/kg/m, nearly twice normal. Both interventions increased gait speed (TC by 0.21 …
RESULTS: Of 50 participants (mean age, 77.2 +/- 5.5 years, 65% women), 47 completed the study. Baseline gait speed was 0.85 +/- 0.13 m …
Age-related striatal dopaminergic denervation and severity of a slip perturbation.
Cham R, Perera S, Studenski SA, Bohnen NI. Cham R, et al. J Gerontol A Biol Sci Med Sci. 2011 Sep;66(9):980-5. doi: 10.1093/gerona/glr060. Epub 2011 Jul 11. J Gerontol A Biol Sci Med Sci. 2011. PMID: 21746736 Free PMC article.
The magnitude of a slip was quantified using the peak slip velocity (PSV), measured at the slipping foot. Data were analyzed for both fast (greater than 1.2 m/s) and slow walkers as gait speed correlated with slip severity. ...RESULTS: Greater severity of dopaminergic dene …
The magnitude of a slip was quantified using the peak slip velocity (PSV), measured at the slipping foot. Data were analyzed for both fast ( …
Phenotypic and genetic characterization of MERS coronaviruses from Africa to understand their zoonotic potential.
Zhou Z, Hui KPY, So RTY, Lv H, Perera RAPM, Chu DKW, Gelaye E, Oyas H, Njagi O, Abayneh T, Kuria W, Walelign E, Wanglia R, El Masry I, Von Dobschuetz S, Kalpravidh W, Chevalier V, Miguel E, Fassi-Fihri O, Trarore A, Liang W, Wang Y, Nicholls JM, Zhao J, Chan MCW, Poon LLM, Mok CKP, Peiris M. Zhou Z, et al. Proc Natl Acad Sci U S A. 2021 Jun 22;118(25):e2103984118. doi: 10.1073/pnas.2103984118. Proc Natl Acad Sci U S A. 2021. PMID: 34099577 Free PMC article.
Magnitude and patterns of decline in health and function in 1 year affect subsequent 5-year survival.
Perera S, Studenski S, Chandler JM, Guralnik JM. Perera S, et al. J Gerontol A Biol Sci Med Sci. 2005 Jul;60(7):894-900. doi: 10.1093/gerona/60.7.894. J Gerontol A Biol Sci Med Sci. 2005. PMID: 16079214
Independent contributions were found for decline in gait speed (p =.001 to.002), Short Physical Performance Battery (p =.014 to.026), global health (p <.001), and activities of daily living (p =.005 to.019). ...Persistent decline in 1 year consisten …
Independent contributions were found for decline in gait speed (p =.001 to.002), Short Physical Performance Battery (p =.014 t …