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Page 1
Synthesis of New Triazole-Based Thiosemicarbazone Derivatives as Anti-Alzheimer's Disease Candidates: Evidence-Based In Vitro Study.
Rahim F, Ullah H, Taha M, Hussain R, Sarfraz M, Iqbal R, Iqbal N, Khan S, Ali Shah SA, Albalawi MA, Abdelaziz MA, Alatawi FS, Alasmari A, Sakran MI, Zidan N, Jafri I, Khan KM. Rahim F, et al. Among authors: iqbal n. Molecules. 2022 Dec 20;28(1):21. doi: 10.3390/molecules28010021. Molecules. 2022. PMID: 36615218 Free PMC article.
All derivatives (except 6c and 6d, which were found to be completely inactive) demonstrated moderate to good inhibitory effects ranging from 0.10 0.050 to 12.20 0.30 M (for AChE) and 0.20 0.10 to 14.10 0.40 M (for BuChE). The analogue 6i (IC(50) = 0.10 0.050 for ACh …
All derivatives (except 6c and 6d, which were found to be completely inactive) demonstrated moderate to good inhibitory effects ranging from …
An effort to find new α-amylase inhibitors as potent antidiabetics compounds based on indole-based-thiadiazole analogs.
Taha M, Uddin N, Saad SM, Iqbal N, Fareed G, Anouar EH, Hassan MH, Almandil NB, Salahuddin M, Khan KM, Wadood A, Rahman AU. Taha M, et al. Among authors: iqbal n. J Biomol Struct Dyn. 2022;40(23):13103-13114. doi: 10.1080/07391102.2021.1982774. Epub 2021 Sep 27. J Biomol Struct Dyn. 2022. PMID: 34569449
All synthetic compounds, except 4, 13, 15 and 16, were found to be strongly active (IC(50) values in the range of 0.80 0.05 - 9.30 0.20 M) than the standard drug, acarbose (IC(50) = 11.70 0.10 M). Nevertheless, compound 18 was found to be inactive. ...
All synthetic compounds, except 4, 13, 15 and 16, were found to be strongly active (IC(50) values in the range of 0.80 0.05 - 9.30 0.20 M …
Synthesis, in vitro antiurease, in vivo antinematodal activity of quinoline analogs and their in-silico study.
Zaman K, Rahim F, Taha M, Sajid M, Hayat S, Nawaz M, Salahuddin M, Iqbal N, Khan NU, Shah SAA, Farooq RK, Bahadar A, Wadood A, Khan KM. Zaman K, et al. Among authors: iqbal n. Bioorg Chem. 2021 Oct;115:105199. doi: 10.1016/j.bioorg.2021.105199. Epub 2021 Jul 22. Bioorg Chem. 2021. PMID: 34329995
Synthesis of quinoline analogs and their urease inhibitory activities with reference to the standard drug, thiourea (IC(50) = 21.86 0.40 M) are presented in this study. The inhibitory activity range is (IC(50) = 0.60 0.01 to 24.10 0.70 M) which displayed that it is …
Synthesis of quinoline analogs and their urease inhibitory activities with reference to the standard drug, thiourea (IC(50) = 21.86 0.40 …
Synthesis, DFT Studies, Molecular Docking and Biological Activity Evaluation of Thiazole-Sulfonamide Derivatives as Potent Alzheimer's Inhibitors.
Khan S, Ullah H, Taha M, Rahim F, Sarfraz M, Iqbal R, Iqbal N, Hussain R, Ali Shah SA, Ayub K, Albalawi MA, Abdelaziz MA, Alatawi FS, Khan KM. Khan S, et al. Among authors: iqbal n. Molecules. 2023 Jan 5;28(2):559. doi: 10.3390/molecules28020559. Molecules. 2023. PMID: 36677616 Free PMC article.
All analogs exhibited a varied degree of inhibitory potential, but analog 1 was found to have excellent potency (IC(50) = 0.10 0.05 M for AChE) and (IC(50) = 0.20 0.050 M for BuChE) as compared to the reference drug donepezil (IC(50) = 2.16 0.12 M and 4.5 0.1 …
All analogs exhibited a varied degree of inhibitory potential, but analog 1 was found to have excellent potency (IC(50) = 0.10 0.05 M …
Synthesis of indole-based-thiadiazole derivatives as a potent inhibitor of α-glucosidase enzyme along with in silico study.
Alomari M, Taha M, Rahim F, Selvaraj M, Iqbal N, Chigurupati S, Hussain S, Uddin N, Almandil NB, Nawaz M, Khalid Farooq R, Khan KM. Alomari M, et al. Among authors: iqbal n. Bioorg Chem. 2021 Mar;108:104638. doi: 10.1016/j.bioorg.2021.104638. Epub 2021 Jan 8. Bioorg Chem. 2021. PMID: 33508679
All analogs showed varied alpha-glucosidase inhibitory potential with IC(50) value ranged between 0.95 0.05 to 13.60 0.30 M, when compared with the standard acarbose (IC(50) = 1.70 0.10). Analogs 17, 2, 1, 9, 7, 3, 15, 10, 16, and 14 with IC(50) values 0.95 0.05, 1.10 0.10 …
All analogs showed varied alpha-glucosidase inhibitory potential with IC(50) value ranged between 0.95 0.05 to 13.60 0.30 M, when com …
New biologically dynamic hybrid pharmacophore triazinoindole-based-thiadiazole as potent α-glucosidase inhibitors: In vitro and in silico study.
Khan AA, Rahim F, Taha M, Rehman W, Iqbal N, Wadood A, Ahmad N, Shah SAA, Ghoneim MM, Alshehri S, Salahuddin M, Khan KM. Khan AA, et al. Among authors: iqbal n. Int J Biol Macromol. 2022 Feb 28;199:77-85. doi: 10.1016/j.ijbiomac.2021.12.147. Epub 2021 Dec 27. Int J Biol Macromol. 2022. PMID: 34968547
All synthesized analogues showed outstanding inhibition of alpha-glucosidase enzyme with IC(50) values ranging from 2.5 0.10 to 38.10 0.10 M as compared to the standard drug acarbose (IC(50) = 38.45 0.80 M). Analogue 4 (IC(50) = 2.5 0.10 M) was identifies as …
All synthesized analogues showed outstanding inhibition of alpha-glucosidase enzyme with IC(50) values ranging from 2.5 0.10 to 38.10 0.10 …
Synthesis, In Vitro Biological Evaluation and Molecular Modeling of Benzimidazole-Based Pyrrole/Piperidine Hybrids Derivatives as Potential Anti-Alzheimer Agents.
Tariq S, Rahim F, Ullah H, Sarfraz M, Hussain R, Khan S, Khan MU, Rehman W, Hussain A, Bhat MA, Farooqi MK, Shah SAA, Iqbal N. Tariq S, et al. Among authors: iqbal n. Pharmaceuticals (Basel). 2024 Mar 24;17(4):410. doi: 10.3390/ph17040410. Pharmaceuticals (Basel). 2024. PMID: 38675373 Free PMC article.
Synthesized compounds (1-13) were screened in cholinesterase enzyme inhibition assays and showed AChE activities in the range of IC(50) = 19.44 0.60 M to 36.05 0.4 M against allanzanthane (IC(50) = 16.11 0.33 M) and galantamine (IC(50) = 19.34 0.62 M) …
Synthesized compounds (1-13) were screened in cholinesterase enzyme inhibition assays and showed AChE activities in the range of IC(50) = 19 …
Synthesis of indole based acetohydrazide analogs: Their in vitro and in silico thymidine phosphorylase studies.
Taha M, Aldhamin EAJ, Almandil NB, Anouar EH, Uddin N, Alomari M, Rahim F, Adalat B, Ibrahim M, Nawaz F, Iqbal N, Alghanem B, Altolayyan A, Khan KM. Taha M, et al. Among authors: iqbal n. Bioorg Chem. 2020 May;98:103745. doi: 10.1016/j.bioorg.2020.103745. Epub 2020 Mar 12. Bioorg Chem. 2020. PMID: 32200327
These derivatives inhibited thymidine phosphorylase at different concentration ranging from 1.10 0.10 to 41.10 1.10 M when compared with the standard 7-Deazaxanthine (IC(50) value 38.68 1.12 M). The compound 8 having OH group at 2, 4 and 6 position was found the mos …
These derivatives inhibited thymidine phosphorylase at different concentration ranging from 1.10 0.10 to 41.10 1.10 M when compared w …
Evaluation and docking of indole sulfonamide as a potent inhibitor of α-glucosidase enzyme in streptozotocin -induced diabetic albino wistar rats.
Taha M, Imran S, Salahuddin M, Iqbal N, Rahim F, Uddin N, Shehzad A, Khalid Farooq R, Alomari M, Mohammed Khan K. Taha M, et al. Among authors: iqbal n. Bioorg Chem. 2021 May;110:104808. doi: 10.1016/j.bioorg.2021.104808. Epub 2021 Mar 10. Bioorg Chem. 2021. PMID: 33756236
All scaffolds were found to be active except scaffold 17 and exhibited IC(50) values ranging from 1.60 to 51.20 M in comparison with standard acarbose (IC(50) = 42.45 M). Among the synthesized hybrid class scaffolds 16 was the most potent analogue with IC(50) value …
All scaffolds were found to be active except scaffold 17 and exhibited IC(50) values ranging from 1.60 to 51.20 M in comparison with …
12 results