Pharmacological attenuation of melanoma by tryptanthrin pertains to the suppression of MITF-M through MEK/ERK signaling axis.
Shabna A, Antony J, Vijayakurup V, Saikia M, Liju VB, Retnakumari AP, Amrutha NA, Alex VV, Swetha M, Aiswarya SU, Jannet S, Unni US, Sundaram S, Sherin DR, Anto NP, Bava SV, Chittalakkottu S, Ran S, Anto RJ.
Shabna A, et al.
Cell Mol Life Sci. 2022 Aug 10;79(9):478. doi: 10.1007/s00018-022-04476-y.
Cell Mol Life Sci. 2022.
PMID: 35948813
A major mechanism by which melanoma cells attain therapy resistance is via the activation of microphthalmia-associated transcription factor-M (MITF-M), the key transcription factor and oncogene aiding the survival of melanoma cells. ...Tpn potentiates the degradatio …
A major mechanism by which melanoma cells attain therapy resistance is via the activation of microphthalmia-associated transcription factor- …