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Non-covalent SARS-CoV-2 M(pro) inhibitors developed from in silico screen hits.
Rossetti GG, Ossorio MA, Rempel S, Kratzel A, Dionellis VS, Barriot S, Tropia L, Gorgulla C, Arthanari H, Thiel V, Mohr P, Gamboni R, Halazonetis TD. Rossetti GG, et al. Sci Rep. 2022 Feb 15;12(1):2505. doi: 10.1038/s41598-022-06306-4. Sci Rep. 2022. PMID: 35169179 Free PMC article.
M(pro), the main protease of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is essential for the viral life cycle. ...The compounds of the first chemotype denatured M(pro) and were considered not useful for further development. ...
M(pro), the main protease of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is essential for the viral life cycle. …
The A, M, N, and P1 blood group substances in butanol extracts of human erythrocytes.
Lambert RM, Kratzel RJ, Zelenski KR. Lambert RM, et al. Immunol Commun. 1978;7(4):461-70. doi: 10.3109/08820137809047629. Immunol Commun. 1978. PMID: 669752
Group A substance was recovered in both aqueous phase and butanol phase extracts, M and N substance in aqueous phase extracts only, and P1 substance only in butanol phase extracts. Use of high concentrations of extract resulted in detection of P1 activity in aqueous phase …
Group A substance was recovered in both aqueous phase and butanol phase extracts, M and N substance in aqueous phase extracts only, a …
Decontamination of surgical instruments from prions. II. In vivo findings with a model system for testing the removal of scrapie infectivity from steel surfaces.
Lemmer K, Mielke M, Kratzel C, Joncic M, Oezel M, Pauli G, Beekes M. Lemmer K, et al. J Gen Virol. 2008 Jan;89(Pt 1):348-358. doi: 10.1099/vir.0.83396-0. J Gen Virol. 2008. PMID: 18089760
In the search for effective, instrument-compatible and routinely applicable decontamination procedures, a previous study [Lemmer, K., Mielke, M., Pauli, G. & Beekes, M. (2004). J Gen Virol 85, 3805-3816] identified promising reagents in an in vitro carrier assay …
In the search for effective, instrument-compatible and routinely applicable decontamination procedures, a previous study [Lemmer, K., Mielke …
Synthesis, development and in vitro evaluation of drug delivery systems with protective effect against degradation by pepsin.
Bernkop-Schnürch A, Kirchmayer R, Kratzel M. Bernkop-Schnürch A, et al. J Drug Target. 1999;7(1):55-63. doi: 10.3109/10611869909085492. J Drug Target. 1999. PMID: 10614815
The IC50 of this novel inhibitor was determined to be 6.65+/-1.05x10(-6) M. Mediated by a carbodiimide it was covalently bound to polycarbophil and sodium carboxy-methyl cellulose (NaCMC). ...
The IC50 of this novel inhibitor was determined to be 6.65+/-1.05x10(-6) M. Mediated by a carbodiimide it was covalently bound to pol …