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Effect of structured physical activity on prevention of major mobility disability in older adults: the LIFE study randomized clinical trial.
Pahor M, Guralnik JM, Ambrosius WT, Blair S, Bonds DE, Church TS, Espeland MA, Fielding RA, Gill TM, Groessl EJ, King AC, Kritchevsky SB, Manini TM, McDermott MM, Miller ME, Newman AB, Rejeski WJ, Sink KM, Williamson JD; LIFE study investigators. Pahor M, et al. JAMA. 2014 Jun 18;311(23):2387-96. doi: 10.1001/jama.2014.5616. JAMA. 2014. PMID: 24866862 Free PMC article. Clinical Trial.
We randomized a volunteer sample of 1635 sedentary men and women aged 70 to 89 years who had physical limitations, defined as a score on the Short Physical Performance Battery of 9 or below, but were able to walk 400 m. INTERVENTIONS: Participants were randomized to a stru …
We randomized a volunteer sample of 1635 sedentary men and women aged 70 to 89 years who had physical limitations, defined as a score on the …
Incidence rates of childhood asthma with recurrent exacerbations in the US Environmental influences on Child Health Outcomes (ECHO) program.
Miller RL, Schuh H, Chandran A, Aris IM, Bendixsen C, Blossom J, Breton C, Camargo CA Jr, Canino G, Carroll KN, Commodore S, Cordero JF, Dabelea DM, Ferrara A, Fry RC, Ganiban JM, Gern JE, Gilliland FD, Gold DR, Habre R, Hare ME, Harte RN, Hartert T, Hasegawa K, Khurana Hershey GK, Jackson DJ, Joseph C, Kerver JM, Kim H, Litonjua AA, Marsit CJ, McEvoy C, Mendonça EA, Moore PE, Nkoy FL, O'Connor TG, Oken E, Ownby D, Perzanowski M, Rivera-Spoljaric K, Ryan PH, Singh AM, Stanford JB, Wright RJ, Wright RO, Zanobetti A, Zoratti E, Johnson CC; of program collaborators for Environmental influences on Child Health Outcomes. Miller RL, et al. J Allergy Clin Immunol. 2023 Jul;152(1):84-93. doi: 10.1016/j.jaci.2023.03.016. Epub 2023 Mar 25. J Allergy Clin Immunol. 2023. PMID: 36972767
Impact and Lessons From the Lifestyle Interventions and Independence for Elders (LIFE) Clinical Trials of Physical Activity to Prevent Mobility Disability.
Pahor M, Guralnik JM, Anton SD, Ambrosius WT, Blair SN, Church TS, Espeland MA, Fielding RA, Gill TM, Glynn NW, Groessl EJ, King AC, Kritchevsky SB, Manini TM, McDermott MM, Miller ME, Newman AB, Williamson JD. Pahor M, et al. J Am Geriatr Soc. 2020 Apr;68(4):872-881. doi: 10.1111/jgs.16365. Epub 2020 Feb 27. J Am Geriatr Soc. 2020. PMID: 32105353 Free PMC article. Review.
The LIFE Study, involving 1635 participants randomized at eight sites throughout the United States, showed that compared with health education, the physical activity program reduced the risk of the primary outcome of MMD (inability to walk 400 m: hazard ratio = 0.82; 95% c …
The LIFE Study, involving 1635 participants randomized at eight sites throughout the United States, showed that compared with health educati …
MR Imaging Characteristics Associate with Tumor-Associated Macrophages in Glioblastoma and Provide an Improved Signature for Survival Prognostication.
Zhou J, Reddy MV, Wilson BKJ, Blair DA, Taha A, Frampton CM, Eiholzer RA, Gan PYC, Ziad F, Thotathil Z, Kirs S, Hung NA, Royds JA, Slatter TL. Zhou J, et al. AJNR Am J Neuroradiol. 2018 Feb;39(2):252-259. doi: 10.3174/ajnr.A5441. Epub 2017 Nov 30. AJNR Am J Neuroradiol. 2018. PMID: 29191871 Free PMC article.
Glioblastomas were divided into subtypes based on the telomere maintenance mechanism: alternative lengthening of telomeres positive (ALT+) and negative (ALT-) and the content of tumor-associated macrophages (with [M+] or without [M-] a high content of macrophages). …
Glioblastomas were divided into subtypes based on the telomere maintenance mechanism: alternative lengthening of telomeres positive (ALT+) a …
Development and psychometric validation of the Pandemic-Related Traumatic Stress Scale for children and adults.
Blackwell CK, Sherlock P, Jackson KL, Hofheimer JA, Cella D, Algermissen MA, Alshawabkeh AN, Avalos LA, Bastain T, Blair C, Bosquet Enlow M, Brennan PA, Breton C, Bush NR, Chandran A, Collazo S, Conradt E, Crowell SE, Deoni S, Elliott AJ, Frazier JA, Ganiban JM, Gold DR, Herbstman JB, Joseph C, Karagas MR, Lester B, Lasky-Su JA, Leve LD, LeWinn KZ, Mason WA, McGowan EC, McKee KS, Miller RL, Neiderhiser JM, O'Connor TG, Oken E, O'Shea TM, Pagliaccio D, Schmidt RJ, Singh AM, Stanford JB, Trasande L, Wright RJ, Duarte CS, Margolis AE. Blackwell CK, et al. Psychol Assess. 2023 Nov;35(11):1054-1067. doi: 10.1037/pas0001211. Psychol Assess. 2023. PMID: 37902671 Free PMC article.
Rationale and Design of the IROCAS Study: Multicenter, International, Randomized Phase 3 Trial Comparing Adjuvant Modified (m) FOLFIRINOX to mFOLFOX6 in Patients With High-Risk Stage III (pT4 and/or N2) Colon Cancer-A UNICANCER GI-PRODIGE Trial.
Bennouna J, André T, Campion L, Hiret S, Miglianico L, Mineur L, Touchefeu Y, Artru P, Asmis T, Bouché O, Borde F, Kavan P, Lam YH, Rajpar LS, Emile JF, Jouffroy C, Gill S, Taïeb J. Bennouna J, et al. Clin Colorectal Cancer. 2019 Mar;18(1):e69-e73. doi: 10.1016/j.clcc.2018.09.011. Epub 2018 Oct 19. Clin Colorectal Cancer. 2019. PMID: 30415988
Patients will be randomized to receive adjuvant modified FOLFIRINOX (oxaliplatin 85 mg/m(2), leucovorin 400 mg/m(2), irinotecan 180 mg/m(2), and 5-FU 2.4 g/m(2) over 46 hours) or modified FOLFOX6 (oxaliplatin 85 mg/m(2), leucovorin 400 mg/m …
Patients will be randomized to receive adjuvant modified FOLFIRINOX (oxaliplatin 85 mg/m(2), leucovorin 400 mg/m(2), irinoteca …
The MAT-sf: identifying risk for major mobility disability.
Rejeski WJ, Rushing J, Guralnik JM, Ip EH, King AC, Manini TM, Marsh AP, McDermott MM, Fielding RA, Newman AB, Tudor-Locke C, Gill TM; LIFE Study Group. Rejeski WJ, et al. J Gerontol A Biol Sci Med Sci. 2015 May;70(5):641-6. doi: 10.1093/gerona/glv003. Epub 2015 Feb 13. J Gerontol A Biol Sci Med Sci. 2015. PMID: 25680917 Free PMC article.
The MAT-sf was administered at baseline; MMD, operationalized as failure to complete the 400-m walk 15 minutes, was evaluated at 6-month intervals across a period of 42 months. ...
The MAT-sf was administered at baseline; MMD, operationalized as failure to complete the 400-m walk 15 minutes, was evaluated at 6-mo …
The Lifestyle Interventions and Independence for Elders Study: design and methods.
Fielding RA, Rejeski WJ, Blair S, Church T, Espeland MA, Gill TM, Guralnik JM, Hsu FC, Katula J, King AC, Kritchevsky SB, McDermott MM, Miller ME, Nayfield S, Newman AB, Williamson JD, Bonds D, Romashkan S, Hadley E, Pahor M; LIFE Research Group. Fielding RA, et al. J Gerontol A Biol Sci Med Sci. 2011 Nov;66(11):1226-37. doi: 10.1093/gerona/glr123. Epub 2011 Aug 8. J Gerontol A Biol Sci Med Sci. 2011. PMID: 21825283 Free PMC article. Clinical Trial.
RESULTS: LIFE's primary outcome is major mobility disability, defined as the inability to walk 400 m. Secondary outcomes include cognitive function, serious fall injuries, persistent mobility disability, the combined outcome of major mobility disability or death, disabilit …
RESULTS: LIFE's primary outcome is major mobility disability, defined as the inability to walk 400 m. Secondary outcomes include cogn …
Impact of Baseline Fatigue on a Physical Activity Intervention to Prevent Mobility Disability.
Glynn NW, Gmelin T, Santanasto AJ, Lovato LC, Lange-Maia BS, Nicklas BJ, Fielding RA, Manini TM, Myers VH, de Rekeneire N, Spring BJ, Pahor M, King AC, Rejeski WJ, Newman AB; Lifestyle Interventions and Independence for Elders Study Group. Glynn NW, et al. J Am Geriatr Soc. 2020 Mar;68(3):619-624. doi: 10.1111/jgs.16274. Epub 2019 Dec 22. J Am Geriatr Soc. 2020. PMID: 31867713 Free PMC article. Clinical Trial.
Total score was calculated by averaging across questions; baseline fatigue was based on the median split: 2 or higher = more fatigue (N = 856) and lower than 2 = less fatigue (N = 735). Participants performed a usual-paced 400-m walk every 6 months. We defined incident MMD …
Total score was calculated by averaging across questions; baseline fatigue was based on the median split: 2 or higher = more fatigue (N = 85 …
Effect of Physical Activity versus Health Education on Physical Function, Grip Strength and Mobility.
Santanasto AJ, Glynn NW, Lovato LC, Blair SN, Fielding RA, Gill TM, Guralnik JM, Hsu FC, King AC, Strotmeyer ES, Manini TM, Marsh AP, McDermott MM, Goodpaster BH, Pahor M, Newman AB; LIFE Study Group. Santanasto AJ, et al. J Am Geriatr Soc. 2017 Jul;65(7):1427-1433. doi: 10.1111/jgs.14804. Epub 2017 Feb 21. J Am Geriatr Soc. 2017. PMID: 28221668 Free PMC article. Clinical Trial.
OUTCOMES: Grip strength, SPPB score and its components (balance, 4 m gait speed, and chair-stands), as well as 400 m walking speed. ...However, 400 m walking speed was faster in PA versus HE group (overall P =<.001). ...
OUTCOMES: Grip strength, SPPB score and its components (balance, 4 m gait speed, and chair-stands), as well as 400 m walking s …
16 results