Dammarane triterpenes targeting α-synuclein: biological activity and evaluation of binding sites by molecular docking.
Cornejo A, Caballero J, Simirgiotis M, Torres V, Sánchez L, Díaz N, Guimaraes M, Hernández M, Areche C, Alfaro S, Caballero L, Melo F.
Cornejo A, et al.
J Enzyme Inhib Med Chem. 2021 Dec;36(1):154-162. doi: 10.1080/14756366.2020.1851216.
J Enzyme Inhib Med Chem. 2021.
PMID: 33307873
Free PMC article.
Since compound 1 was most active, we determined the interaction between alpha-synuclein and 1 at 50 M (Kd) through microscale thermophoresis. Also, we observed differences in height and diameter of aggregates, and alpha-synuclein remains unfolded in the presence of 1. ...
Since compound 1 was most active, we determined the interaction between alpha-synuclein and 1 at 50 M (Kd) through microscale thermop …