MALDI(+) FT-ICR Mass Spectrometry (MS) Combined with Machine Learning toward Saliva-Based Diagnostic Screening for COVID-19.
de Almeida CM, Motta LC, Folli GS, Marcarini WD, Costa CA, Vilela ACS, Barauna VG, Martin FL, Singh MN, Campos LCG, Costa NL, Vassallo PF, Chaves AR, Endringer DC, Mill JG, Filgueiras PR, Romão W.
de Almeida CM, et al.
J Proteome Res. 2022 Aug 5;21(8):1868-1875. doi: 10.1021/acs.jproteome.2c00148. Epub 2022 Jul 25.
J Proteome Res. 2022.
PMID: 35880262
In the method optimization, the best sample preparation was obtained with the digestion of saliva in 10 muL of trypsin for 2 h and the MALDI analysis, which presented a satisfactory resolution for the analysis with 1 M. SVM models were created with data from the analysis o …
In the method optimization, the best sample preparation was obtained with the digestion of saliva in 10 muL of trypsin for 2 h and the MALDI …