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Delivery of oligonucleotide-based therapeutics: challenges and opportunities.
Hammond SM, Aartsma-Rus A, Alves S, Borgos SE, Buijsen RAM, Collin RWJ, Covello G, Denti MA, Desviat LR, Echevarría L, Foged C, Gaina G, Garanto A, Goyenvalle AT, Guzowska M, Holodnuka I, Jones DR, Krause S, Lehto T, Montolio M, Van Roon-Mom W, Arechavala-Gomeza V. Hammond SM, et al. EMBO Mol Med. 2021 Apr 9;13(4):e13243. doi: 10.15252/emmm.202013243. Epub 2021 Apr 6. EMBO Mol Med. 2021. PMID: 33821570 Free PMC article. Review.
Quantitative multiple fragment monitoring with enhanced in-source fragmentation/annotation mass spectrometry.
Bernardo-Bermejo S, Xue J, Hoang L, Billings E, Webb B, Honders MW, Venneker S, Heijs B, Castro-Puyana M, Marina ML, van den Akker EB, Griffioen M, Siuzdak G, Giera M, Sánchez-López E. Bernardo-Bermejo S, et al. Nat Protoc. 2023 Apr;18(4):1296-1315. doi: 10.1038/s41596-023-00803-0. Epub 2023 Feb 8. Nat Protoc. 2023. PMID: 36755131 Free PMC article. Review.
We recently showed that it is possible to generate very similar results using a much simpler single mass spectrometry detector by performing enhanced in-source fragmentation/annotation (EISA) combined with correlated ion monitoring. Here we provide a step-by-step protocol …
We recently showed that it is possible to generate very similar results using a much simpler single mass spectrometry detector by performing …
Test-Retest Reliability of the Electronic Instrumental activities of daily living Satisfaction Assessment (EISA): A Cohort Study.
Quamar AH, Schmeler MR, McCue M, Cooper RA, Goldberg MR, DiGiovine C, Collins DM, Schein RM. Quamar AH, et al. Am J Occup Ther. 2023 Nov 1;77(6):7706205140. doi: 10.5014/ajot.2023.050285. Am J Occup Ther. 2023. PMID: 38051265 Free PMC article.
OUTCOMES AND MEASURES: The a priori study hypotheses were that the EISA test-retest reliability scores would be above the minimum acceptable level (Rs > .80) and that internal consistency would be good (Cronbach's alpha = .70-.90). RESULTS: On the basis of the study dat …
OUTCOMES AND MEASURES: The a priori study hypotheses were that the EISA test-retest reliability scores would be above the minimum acc …
Enhanced in-Source Fragmentation Annotation Enables Novel Data Independent Acquisition and Autonomous METLIN Molecular Identification.
Xue J, Domingo-Almenara X, Guijas C, Palermo A, Rinschen MM, Isbell J, Benton HP, Siuzdak G. Xue J, et al. Anal Chem. 2020 Apr 21;92(8):6051-6059. doi: 10.1021/acs.analchem.0c00409. Epub 2020 Apr 10. Anal Chem. 2020. PMID: 32242660 Free PMC article.
Enhanced ISF as compared to QTOF DDA enabled higher peak intensities for the precursor ions (median: 18 times in negative mode and 210 times in positive mode), with the eISA fragmentation patterns consistent with METLIN for over 90% of the molecules with respect to fragmen …
Enhanced ISF as compared to QTOF DDA enabled higher peak intensities for the precursor ions (median: 18 times in negative mode and 210 times …
Trypsin-Instructed Self-Assembly on Endoplasmic Reticulum for Selectively Inhibiting Cancer Cells: Dedicated to Professor George M. Whitesides on the occasion of his 80th birthday.
Kim BJ, Fang Y, He H, Xu B. Kim BJ, et al. Adv Healthc Mater. 2021 Feb;10(4):e2000416. doi: 10.1002/adhm.202000416. Epub 2020 Apr 28. Adv Healthc Mater. 2021. PMID: 32342647 Free PMC article.
Selectively targeting the endoplasmic reticulum (ER) of cancer cells, though promising a new strategy for cancer therapy, remains underdeveloped. Enzyme-instructed self-assembly (EISA) is emerging as a promising approach for selectively targeting ER of cancer cells. This w …
Selectively targeting the endoplasmic reticulum (ER) of cancer cells, though promising a new strategy for cancer therapy, remains underdevel …
Using a Clinicopathologic and Gene Expression (CP-GEP) Model to Identify Stage I-II Melanoma Patients at Risk of Disease Relapse.
Mulder EEAP, Johansson I, Grünhagen DJ, Tempel D, Rentroia-Pacheco B, Dwarkasing JT, Verver D, Mooyaart AL, van der Veldt AAM, Wakkee M, Nijsten TEC, Verhoef C, Mattsson J, Ny L, Hollestein LM, Olofsson Bagge R. Mulder EEAP, et al. Cancers (Basel). 2022 Jun 9;14(12):2854. doi: 10.3390/cancers14122854. Cancers (Basel). 2022. PMID: 35740520 Free PMC article.
Mesoporous titanium dioxide coating for metallic implants.
Xia W, Grandfield K, Hoess A, Ballo A, Cai Y, Engqvist H. Xia W, et al. J Biomed Mater Res B Appl Biomater. 2012 Jan;100(1):82-93. doi: 10.1002/jbm.b.31925. Epub 2011 Sep 27. J Biomed Mater Res B Appl Biomater. 2012. PMID: 21954047
A bioactive mesoporous titanium dioxide (MT) coating for surface drug delivery has been investigated to develop a multifunctional implant coating, offering quick bone bonding and biological stability. An evaporation induced self-assembly (EISA) method was used to prepare a …
A bioactive mesoporous titanium dioxide (MT) coating for surface drug delivery has been investigated to develop a multifunctional implant co …
The educational value of ward rounds as a learning and teaching opportunity for house officers, medical officers, and registrars in Sudanese hospitals: a multi-center cross-sectional study.
Eljack MMF, Ahmed FMT, Hasabo EA, Alfatih M, Ahmed KAHM, Elnaiem W, Mohamed MTA, Ahmed A, Hamood FMM, Hajhamd AAI, Ahmed RMM, Mansoor AFAB, Ahmed EM, Eisa YMEA, Taha NYM, Ahmed ME, Alnour AAD, Tayfour DOA, Mohammed LM, Ahmed EAZE, Tajeldeen S, Abdelrasoul MA, Balla IMM, Fadl HAO, Ahmed TAH, Yousif A, Abdulrazique QA, Sabri M, Dafalla HN, Alrahaman MF, Mohamed FRG, Ahmed AMOB, Alrabee NHK, Elbannan Elhassan Mohamed Ali M, Ali MM, Ibrahim AAA, A Wahaballah A, Elbagir M, Alkhier EA, Ahmed MA, Mustafa A, Altigany AK, Elaagib A, Almakey Y, Altayeb IKM, Humida G, Mohamed MHA, Ali ATM, Ahmed OMM. Eljack MMF, et al. BMC Med Educ. 2023 Jun 8;23(1):426. doi: 10.1186/s12909-023-04404-z. BMC Med Educ. 2023. PMID: 37291568 Free PMC article.
An average of 3.1 6.8 ward rounds were conducted per week in our hospitals, with 11.1 20.3 h spent on ward rounds per week. Most doctors agreed that ward rounds are suitable for teaching patient management (91.3%) and diagnostic investigations (89.1%). ...
An average of 3.1 6.8 ward rounds were conducted per week in our hospitals, with 11.1 20.3 h spent on ward rounds per week. Most doct …
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