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Molnupiravir for Oral Treatment of Covid-19 in Nonhospitalized Patients.
Jayk Bernal A, Gomes da Silva MM, Musungaie DB, Kovalchuk E, Gonzalez A, Delos Reyes V, Martín-Quirós A, Caraco Y, Williams-Diaz A, Brown ML, Du J, Pedley A, Assaid C, Strizki J, Grobler JA, Shamsuddin HH, Tipping R, Wan H, Paschke A, Butterton JR, Johnson MG, De Anda C; MOVe-OUT Study Group. Jayk Bernal A, et al. N Engl J Med. 2022 Feb 10;386(6):509-520. doi: 10.1056/NEJMoa2116044. Epub 2021 Dec 16. N Engl J Med. 2022. PMID: 34914868 Free PMC article. Clinical Trial.
Whole-genome sequencing reveals host factors underlying critical COVID-19.
Kousathanas A, Pairo-Castineira E, Rawlik K, Stuckey A, Odhams CA, Walker S, Russell CD, Malinauskas T, Wu Y, Millar J, Shen X, Elliott KS, Griffiths F, Oosthuyzen W, Morrice K, Keating S, Wang B, Rhodes D, Klaric L, Zechner M, Parkinson N, Siddiq A, Goddard P, Donovan S, Maslove D, Nichol A, Semple MG, Zainy T, Maleady-Crowe F, Todd L, Salehi S, Knight J, Elgar G, Chan G, Arumugam P, Patch C, Rendon A, Bentley D, Kingsley C, Kosmicki JA, Horowitz JE, Baras A, Abecasis GR, Ferreira MAR, Justice A, Mirshahi T, Oetjens M, Rader DJ, Ritchie MD, Verma A, Fowler TA, Shankar-Hari M, Summers C, Hinds C, Horby P, Ling L, McAuley D, Montgomery H, Openshaw PJM, Elliott P, Walsh T, Tenesa A; GenOMICC investigators; 23andMe investigators; COVID-19 Human Genetics Initiative; Fawkes A, Murphy L, Rowan K, Ponting CP, Vitart V, Wilson JF, Yang J, Bretherick AD, Scott RH, Hendry SC, Moutsianas L, Law A, Caulfield MJ, Baillie JK. Kousathanas A, et al. Nature. 2022 Jul;607(7917):97-103. doi: 10.1038/s41586-022-04576-6. Epub 2022 Mar 7. Nature. 2022. PMID: 35255492 Free PMC article.
2-Methyl-sulfanyl-9H-1,3,4-thia-diazolo[2,3-b]quinazolin-9-one.
El-Azab AS, Abdel-Aziz AA, Al-Swaidan IA, Ng SW, Tiekink ER. El-Azab AS, et al. Acta Crystallogr Sect E Struct Rep Online. 2012 Jul 1;68(Pt 7):o2134. doi: 10.1107/S1600536812026189. Epub 2012 Jun 20. Acta Crystallogr Sect E Struct Rep Online. 2012. PMID: 22798810 Free PMC article.
In the title compound, C(10)H(7)N(3)OS(2), the 16 non-H atoms are almost planar (r.m.s. deviation = 0.037 A) and the S-bound methyl group is syn to the ketone O atom. In the crystal, centrosymmetrically related mol-ecules are connected by pairs of C-HO inter- …
In the title compound, C(10)H(7)N(3)OS(2), the 16 non-H atoms are almost planar (r.m.s. deviation = 0.037 A) and the S- …
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M, Agostinis P, Agrewala JN, Agrotis A, Aguilar PV, Ahmad ST, Ahmed ZM, Ahumada-Castro U, Aits S, Aizawa S, Akkoc Y, Akoumianaki T, Akpinar HA, Al-Abd AM, Al-Akra L, Al-Gharaibeh A, Alaoui-Jamali MA, Alberti S, Alcocer-Gómez E, Alessandri C, Ali M, Alim Al-Bari MA, Aliwaini S, Alizadeh J, Almacellas E, Almasan A, Alonso A, Alonso GD, Altan-Bonnet N, Altieri DC, Álvarez ÉMC, Alves S, Alves da Costa C, Alzaharna MM, Amadio M, Amantini C, Amaral C, Ambrosio S, Amer AO, Ammanathan V, An Z, Andersen SU, Andrabi SA, Andrade-Silva M, Andres AM, Angelini S, Ann D, Anozie UC, Ansari MY, Antas P, Antebi A, Antón Z, Anwar T, Apetoh L, Apostolova N, Araki T, Araki Y, Arasaki K, Araújo WL, Araya J, Arden C, Arévalo MA, Arguelles S, Arias E, Arikkath J, Arimoto H, Ariosa AR, Armstrong-James D, Arnauné-Pelloquin L, Aroca A, Arroyo DS, Arsov I, Artero R, Asaro DML, Aschner M, Ashrafizadeh M, Ashur-Fabian O, Atanasov AG, Au AK, Auberger P, Auner HW, Aurelian L, Autelli R… See abstract for full author list ➔ Klionsky DJ, et al. Autophagy. 2021 Jan;17(1):1-382. doi: 10.1080/15548627.2020.1797280. Epub 2021 Feb 8. Autophagy. 2021. PMID: 33634751 Free PMC article.
3-Chloro-4-methyl-quinolin-2(1H)-one.
Kassem MG, Ghabbour HA, Abdel-Aziz HA, Fun HK, Ooi CW. Kassem MG, et al. Acta Crystallogr Sect E Struct Rep Online. 2012 Apr 1;68(Pt 4):o1043. doi: 10.1107/S1600536812009889. Epub 2012 Mar 14. Acta Crystallogr Sect E Struct Rep Online. 2012. PMID: 22589913 Free PMC article.
The title compound, C(10)H(8)ClNO, is almost planar (r.m.s. deviation for the 13 non-H atoms = 0.023 A). ...
The title compound, C(10)H(8)ClNO, is almost planar (r.m.s. deviation for the 13 non-H atoms = 0.023 A). ...
8-Benz-yloxy-2-methyl-3-(2-methyl-phenyl)quinazolin-4(3H)-one.
El-Azab AS, Abdel-Aziz AA, Ng SW, Tiekink ER. El-Azab AS, et al. Acta Crystallogr Sect E Struct Rep Online. 2012 Mar 1;68(Pt 3):o864-5. doi: 10.1107/S1600536812007362. Epub 2012 Feb 29. Acta Crystallogr Sect E Struct Rep Online. 2012. PMID: 22412719 Free PMC article.
In the title methaqua-lone analogue, C(23)H(20)N(2)O(2), the planes of the terminal aromatic rings [dihedral angle between them = 64.52 (7)] approximately face the fused-ring methyl group and both are twisted with respect to the pyrimidine plane (r.m.s. deviation = …
In the title methaqua-lone analogue, C(23)H(20)N(2)O(2), the planes of the terminal aromatic rings [dihedral angle between them = 64. …
6-(4-Bromo-phen-yl)-3-methyl-7H-1,2,4-triazolo[3,4-b][1,3,4]thia-diazine.
Fun HK, Quah CK, Abdel-Aziz HA, Attia MI. Fun HK, et al. Acta Crystallogr Sect E Struct Rep Online. 2012 Jun 1;68(Pt 6):o1681. doi: 10.1107/S1600536812019885. Epub 2012 May 12. Acta Crystallogr Sect E Struct Rep Online. 2012. PMID: 22719475 Free PMC article.
In the title compound, C(11)H(9)BrN(4)S, the 1,2,4-triazole ring is essentially planar (r.m.s. deviation = 0.020 A) and makes a dihedral angle of 29.1 (5) with the bromo-benzene ring. ...
In the title compound, C(11)H(9)BrN(4)S, the 1,2,4-triazole ring is essentially planar (r.m.s. deviation = 0.020 A) and makes …
A multi-omics approach to delineate sputum microbiome-associated asthma inflammatory phenotypes.
Abdel-Aziz MI, Vijverberg SJH, Neerincx AH, Brinkman P, Wagener AH, Riley JH, Sousa AR, Bates S, Wagers SS, De Meulder B, Auffray C, Wheelock ÅM, Bansal AT, Caruso M, Chanez P, Uddin M, Corfield J, Horvath I, Krug N, Musial J, Sun K, Shaw DE, Sandström T, Montuschi P, Fowler SJ, Lutter R, Djukanovic R, Howarth P, Skipp P, Sanak M, Adcock IM, Chung KF, Sterk PJ, Kraneveld AD, Maitland-van der Zee AH; U-BIOPRED Study Group. Abdel-Aziz MI, et al. Eur Respir J. 2022 Jan 13;59(1):2102603. doi: 10.1183/13993003.02603-2021. Print 2022 Jan. Eur Respir J. 2022. PMID: 34824056 Free article. No abstract available.
Precision Medicine for More Oxygen (P4O2)-Study Design and First Results of the Long COVID-19 Extension.
Baalbaki N, Blankestijn JM, Abdel-Aziz MI, de Backer J, Bazdar S, Beekers I, Beijers RJHCG, van den Bergh JP, Bloemsma LD, Bogaard HJ, van Bragt JJMH, van den Brink V, Charbonnier JP, Cornelissen MEB, Dagelet Y, Davies EH, van der Does AM, Downward GS, van Drunen CM, Gach D, Geelhoed JJM, Glastra J, Golebski K, Heijink IH, Holtjer JCS, Holverda S, Houweling L, Jacobs JJL, Jonker R, Kos R, Langen RCJ, van der Lee I, Leliveld A, Mohamed Hoesein FAA, Neerincx AH, Noij L, Olsson J, van de Pol M, Pouwels SD, Rolink E, Rutgers M, Șahin H, Schaminee D, Schols AMWJ, Schuurman L, Slingers G, Smeenk O, Sondermeijer B, Skipp PJ, Tamarit M, Verkouter I, Vermeulen R, de Vries R, Weersink EJM, van de Werken M, de Wit-van Wijck Y, Young S, Nossent EJ, Maitland-van der Zee AH; P4O2 consortium. Baalbaki N, et al. J Pers Med. 2023 Jun 28;13(7):1060. doi: 10.3390/jpm13071060. J Pers Med. 2023. PMID: 37511673 Free PMC article.
1-Chloro-1-[(Z)-2-phenyl-hydrazin-1-yl-idene]propan-2-one.
Abdel-Aziz HA, Chia TS, Fun HK. Abdel-Aziz HA, et al. Acta Crystallogr Sect E Struct Rep Online. 2012 Jul 1;68(Pt 7):o2263. doi: 10.1107/S1600536812028759. Epub 2012 Jun 30. Acta Crystallogr Sect E Struct Rep Online. 2012. PMID: 22798911 Free PMC article.
The title compound, C(9)H(9)ClN(2)O, is close to planar (r.m.s. deviation for the non-H atoms = 0.0446 A); it exists in a cis conformation with respect to the C=N double bond. ...
The title compound, C(9)H(9)ClN(2)O, is close to planar (r.m.s. deviation for the non-H atoms = 0.0446 A); it exists in …
83 results