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Year Number of Results
2011 1
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2020 3
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28 results

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Page 1
Antithrombotics from the Sea: Polysaccharides and Beyond.
Carvalhal F, Cristelo RR, Resende DISP, Pinto MMM, Sousa E, Correia-da-Silva M. Carvalhal F, et al. Among authors: sousa e. Mar Drugs. 2019 Mar 16;17(3):170. doi: 10.3390/md17030170. Mar Drugs. 2019. PMID: 30884850 Free PMC article. Review.
Strategies to Overcome Heparins' Low Oral Bioavailability.
Neves AR, Correia-da-Silva M, Sousa E, Pinto M. Neves AR, et al. Among authors: sousa e. Pharmaceuticals (Basel). 2016 Jun 29;9(3):37. doi: 10.3390/ph9030037. Pharmaceuticals (Basel). 2016. PMID: 27367704 Free PMC article. Review.
Antibacterial Potential of Symmetrical Twin-Drug 3,6-Diaminoxanthones.
Resende DISP, Durães F, Zubarioglu S, Freitas-Silva J, Szemerédi N, Pinto M, Pinto E, Martins da Costa P, Spengler G, Sousa E. Resende DISP, et al. Among authors: sousa e. Pharmaceuticals (Basel). 2024 Feb 6;17(2):209. doi: 10.3390/ph17020209. Pharmaceuticals (Basel). 2024. PMID: 38399424 Free PMC article.
Xanthone 16, in particular, has demonstrated exceptional efficacy with a remarkable MIC of 11 M (4 g/mL) against reference strains Staphylococcus aureus ATCC 25923 and Enterococcus faecalis ATCC 29212, and 25 M (9 g/mL) against methicillin-resistant S. aureus 272123 …
Xanthone 16, in particular, has demonstrated exceptional efficacy with a remarkable MIC of 11 M (4 g/mL) against reference strains St …
From Natural Products to New Synthetic Small Molecules: A Journey through the World of Xanthones.
Pinto MMM, Palmeira A, Fernandes C, Resende DISP, Sousa E, Cidade H, Tiritan ME, Correia-da-Silva M, Cravo S. Pinto MMM, et al. Among authors: sousa e. Molecules. 2021 Jan 15;26(2):431. doi: 10.3390/molecules26020431. Molecules. 2021. PMID: 33467544 Free PMC article. Review.
This work reviews the contributions of the corresponding author (M.M.M.P.) and her research group to Medicinal Chemistry concerning the isolation from plant and marine sources of xanthone derivatives as well as their synthesis, biological/pharmacological acti …
This work reviews the contributions of the corresponding author (M.M.M.P.) and her research group to Medicinal Chemistr …
The role of inflammation and antioxidant defenses in the cardiotoxicity of doxorubicin in elderly CD-1 male mice.
Reis-Mendes A, Ferreira M, Duarte JA, Duarte-Araújo M, Remião F, Carvalho F, Sousa E, Bastos ML, Costa VM. Reis-Mendes A, et al. Among authors: sousa e. Arch Toxicol. 2023 Dec;97(12):3163-3177. doi: 10.1007/s00204-023-03586-1. Epub 2023 Sep 7. Arch Toxicol. 2023. PMID: 37676301 Free PMC article.
Elderly (18-20 months) CD-1 male mice received biweekly DOX administrations, for 3 weeks, to reach a cumulative dose of 9.0 mg/kg. One week (1W) or two months (2 M) after the last DOX administration, the heart was collected to determine both drug's short and longer cardiac …
Elderly (18-20 months) CD-1 male mice received biweekly DOX administrations, for 3 weeks, to reach a cumulative dose of 9.0 mg/kg. One week …
Structure-Antifouling Activity Relationship and Molecular Targets of Bio-Inspired(thio)xanthones.
Almeida JR, Palmeira A, Campos A, Cunha I, Freitas M, Felpeto AB, Turkina MV, Vasconcelos V, Pinto M, Correia-da-Silva M, Sousa E. Almeida JR, et al. Among authors: sousa e. Biomolecules. 2020 Jul 30;10(8):1126. doi: 10.3390/biom10081126. Biomolecules. 2020. PMID: 32751491 Free PMC article.
Six (4, 5, 7, 10, 15 and 17) of the tested xanthones showed in vivo activity toward the settlement of Mytilus galloprovincialis larvae (EC(50): 3.53-28.60 M) and low toxicity to this macrofouling species (LC(50) > 500 M and LC(50)/EC(50): 17.42-141.64), and two o …
Six (4, 5, 7, 10, 15 and 17) of the tested xanthones showed in vivo activity toward the settlement of Mytilus galloprovincialis larvae (EC(5 …
Lichen Xanthones as Models for New Antifungal Agents.
Resende DISP, Pereira-Terra P, Inácio ÂS, Costa PMD, Pinto E, Sousa E, Pinto MMM. Resende DISP, et al. Among authors: sousa e. Molecules. 2018 Oct 12;23(10):2617. doi: 10.3390/molecules23102617. Molecules. 2018. PMID: 30322037 Free PMC article.
Among them, 3-chloro-4,6-dimethoxy-1-methyl-9H-xanthen-9-one 15 showed promising antibacterial activity against E. faecalis (ATCC 29212 and 29213) and S. aureus ATCC 29213. 2,7-Dichloro-3,4,6-trimethoxy-1-methyl-9H-xanthen-9-one 18 revealed a potent fungistatic and fungicidal act …
Among them, 3-chloro-4,6-dimethoxy-1-methyl-9H-xanthen-9-one 15 showed promising antibacterial activity against E. faecalis (ATCC 29212 and …
Gallic acid derivatives as inhibitors of mussel (Mytilus galloprovincialis) larval settlement: Lead optimization, biological evaluation and use in antifouling coatings.
Rita Neves A, Vilas Boas C, Gonçalves C, Vasconcelos V, Pinto M, Silva ER, Sousa E, Almeida JR, Correia-da-Silva M. Rita Neves A, et al. Among authors: sousa e. Bioorg Chem. 2022 Sep;126:105911. doi: 10.1016/j.bioorg.2022.105911. Epub 2022 May 25. Bioorg Chem. 2022. PMID: 35661617 Free article.
Following a bioprospection strategy, we have previously reported the AF activity of gallic acid persulfate (1) against the settlement of Mytilus galloprovincialis larvae (EC(50) = 18 M and LC(50)/EC(50) = 27) without exhibiting ecotoxicity to Artemia salina. ...An AF scree …
Following a bioprospection strategy, we have previously reported the AF activity of gallic acid persulfate (1) against the settlement of Myt …
Antifouling Marine Coatings with a Potentially Safer and Sustainable Synthetic Polyphenolic Derivative.
Neves AR, Gomes LC, Faria SI, Sousa J, Ruivo R, Páscoa I, Pinto M, Sousa E, Santos MM, Silva ER, Correia-da-Silva M, Mergulhão F. Neves AR, et al. Among authors: sousa e. Mar Drugs. 2022 Aug 5;20(8):507. doi: 10.3390/md20080507. Mar Drugs. 2022. PMID: 36005510 Free PMC article.
Transcriptional activation of the selected NRs upon exposure to the polyphenolic compound (10 M) was not observed, thus highlighting the eco-friendliness towards the addressed NRs of this new dual-acting anti-macro- and anti-microfouling agent towards the addressed NRs....
Transcriptional activation of the selected NRs upon exposure to the polyphenolic compound (10 M) was not observed, thus highlighting …
Tetracyclic Thioxanthene Derivatives: Studies on Fluorescence and Antitumor Activity.
Durães F, Silva PMA, Novais P, Amorim I, Gales L, Esteves CIC, Guieu S, Bousbaa H, Pinto M, Sousa E. Durães F, et al. Among authors: sousa e. Molecules. 2021 May 31;26(11):3315. doi: 10.3390/molecules26113315. Molecules. 2021. PMID: 34073048 Free PMC article.
Photophysical studies were also performed. Two of the compounds displayed GI(50) values below 10 M for the three tested cell lines, and structure-activity relationship studies were established. ...
Photophysical studies were also performed. Two of the compounds displayed GI(50) values below 10 M for the three tested cell lines, a …
28 results