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Year | Number of Results |
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2014 | 1 |
2020 | 3 |
2021 | 1 |
2022 | 1 |
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Page 1
The Chemotype of Chromanones as a Privileged Scaffold for Multineurotarget Anti-Alzheimer Agents.
ACS Pharmacol Transl Sci. 2022 Oct 12;5(11):1097-1108. doi: 10.1021/acsptsci.2c00097. eCollection 2022 Nov 11.
ACS Pharmacol Transl Sci. 2022.
PMID: 36407962
Free PMC article.
Acetylcholinesterase Inhibition of Diversely Functionalized Quinolinones for Alzheimer's Disease Therapy.
Bautista-Aguilera ÓM, Ismaili L, Chioua M, Andrys R, Schmidt M, Bzonek P, Martínez-Grau MÁ, Beadle CD, Vetman T, López-Muñoz F, Iriepa I, Refouvelet B, Musilek K, Marco-Contelles J.
Bautista-Aguilera ÓM, et al.
Int J Mol Sci. 2020 May 30;21(11):3913. doi: 10.3390/ijms21113913.
Int J Mol Sci. 2020.
PMID: 32486316
Free PMC article.
In particular, molecule QN8 was found to be a potent and quite selective non-competitive inhibitor of hrAChE (IC(50) = 0.29 M), with K(i) value in nanomolar range (79 nM). Pertinent docking analysis confirmed this result, suggesting that this ligand is an interesting hit f …
In particular, molecule QN8 was found to be a potent and quite selective non-competitive inhibitor of hrAChE (IC(50) = 0.29 M), with …
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Homo-Tris-Nitrones Derived from α-Phenyl-N-tert-butylnitrone: Synthesis, Neuroprotection and Antioxidant Properties.
Diez-Iriepa D, Chamorro B, Talaván M, Chioua M, Iriepa I, Hadjipavlou-Litina D, López-Muñoz F, Marco-Contelles J, Oset-Gasque MJ.
Diez-Iriepa D, et al.
Int J Mol Sci. 2020 Oct 26;21(21):7949. doi: 10.3390/ijms21217949.
Int J Mol Sci. 2020.
PMID: 33114714
Free PMC article.
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Privileged Quinolylnitrones for the Combined Therapy of Ischemic Stroke and Alzheimer's Disease.
Alonso JM, Escobar-Peso A, Palomino-Antolín A, Diez-Iriepa D, Chioua M, Martínez-Alonso E, Iriepa I, Egea J, Alcázar A, Marco-Contelles J.
Alonso JM, et al.
Pharmaceuticals (Basel). 2021 Aug 27;14(9):861. doi: 10.3390/ph14090861.
Pharmaceuticals (Basel). 2021.
PMID: 34577561
Free PMC article.
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Isoxazolotacrines as non-toxic and selective butyrylcholinesterase inhibitors for Alzheimer's disease.
Cherif O, Allouche F, Chabchoub F, Chioua M, Soriano E, Yañez M, Cacabelos R, Romero A, López MG, Marco-Contelles J.
Cherif O, et al.
Future Med Chem. 2014;6(17):1883-91. doi: 10.4155/fmc.14.115.
Future Med Chem. 2014.
PMID: 25495982
Novel 3-phenyl-5,6,7,8-tetrahydroisoxazolo[5,4-b]quinolin-4-amine (OC41) is a promising, 31% less toxic than tacrine in HepG2 cells, and selective reversible human butyrylcholinesterase inhibitor (IC50 = 5.08 1.12 M), also showing good drug-like properties according to the …
Novel 3-phenyl-5,6,7,8-tetrahydroisoxazolo[5,4-b]quinolin-4-amine (OC41) is a promising, 31% less toxic than tacrine in HepG2 cells, and sel …
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Synthesis, antioxidant properties and neuroprotection of α-phenyl-tert-butylnitrone derived HomoBisNitrones in in vitro and in vivo ischemia models.
Chamorro B, Diez-Iriepa D, Merás-Sáiz B, Chioua M, García-Vieira D, Iriepa I, Hadjipavlou-Litina D, López-Muñoz F, Martínez-Murillo R, Gonzàlez-Nieto D, Fernández I, Marco-Contelles J, Oset-Gasque MJ.
Chamorro B, et al.
Sci Rep. 2020 Aug 25;10(1):14150. doi: 10.1038/s41598-020-70690-y.
Sci Rep. 2020.
PMID: 32843666
Free PMC article.
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