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Regulation of glycogen synthesis by the laforin-malin complex is modulated by the AMP-activated protein kinase pathway.
Solaz-Fuster MC, Gimeno-Alcañiz JV, Ros S, Fernandez-Sanchez ME, Garcia-Fojeda B, Criado Garcia O, Vilchez D, Dominguez J, Garcia-Rocha M, Sanchez-Piris M, Aguado C, Knecht E, Serratosa J, Guinovart JJ, Sanz P, Rodriguez de Córdoba S. Solaz-Fuster MC, et al. Hum Mol Genet. 2008 Mar 1;17(5):667-78. doi: 10.1093/hmg/ddm339. Epub 2007 Nov 20. Hum Mol Genet. 2008. PMID: 18029386 Free article.
AMP-activated protein kinase phosphorylates R5/PTG, the glycogen targeting subunit of the R5/PTG-protein phosphatase 1 holoenzyme, and accelerates its down-regulation by the laforin-malin complex.
Vernia S, Solaz-Fuster MC, Gimeno-Alcañiz JV, Rubio T, García-Haro L, Foretz M, de Córdoba SR, Sanz P. Vernia S, et al. Among authors: solaz fuster mc. J Biol Chem. 2009 Mar 27;284(13):8247-55. doi: 10.1074/jbc.M808492200. Epub 2009 Jan 26. J Biol Chem. 2009. PMID: 19171932 Free PMC article.