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Microbial life in 25-m-deep boreholes in ancient permafrost illuminated by metagenomics.
Wu X, Almatari AL, Cyr WA, Williams DE, Pfiffner SM, Rivkina EM, Lloyd KG, Vishnivetskaya TA. Wu X, et al. Environ Microbiome. 2023 Apr 13;18(1):33. doi: 10.1186/s40793-023-00487-9. Environ Microbiome. 2023. PMID: 37055869 Free PMC article.
This study describes the composition and potential metabolic adaptation of microbial communities in northeastern Siberia, a repository of the oldest permafrost in the Northern Hemisphere. Samples of contrasting depth (1.75 to 25.1 m below surface), age (from ~ 10 kyr to 1. …
This study describes the composition and potential metabolic adaptation of microbial communities in northeastern Siberia, a repository of th …
Renal cell carcinoma with tumor thrombus: A review of relevant anatomy and surgical techniques for the general urologist.
Almatari AL, Sathe A, Wideman L, Dewan CA, Vaughan JP, Bennie IC, Buscarini M. Almatari AL, et al. Urol Oncol. 2023 Apr;41(4):153-165. doi: 10.1016/j.urolonc.2022.11.021. Epub 2023 Feb 17. Urol Oncol. 2023. PMID: 36804205 Review.
It is known that such tumors are more aggressive with higher Fuhrman grades, N+ or M+ at time of surgery and have higher probability of recurrence with lower cancer-specific survival. ...
It is known that such tumors are more aggressive with higher Fuhrman grades, N+ or M+ at time of surgery and have higher probability …
Up-regulation of SIRT1 induced by 17beta-estradiol promotes autophagy and inhibits apoptosis in osteoblasts.
Wang Y, Mei R, Hao S, Luo P, Wang P, Almatari Y, Guo L, Guo L. Wang Y, et al. Aging (Albany NY). 2021 Oct 28;13(20):23652-23671. doi: 10.18632/aging.203639. Epub 2021 Oct 28. Aging (Albany NY). 2021. PMID: 34711685 Free PMC article.
This study aimed to assess whether the up-regulation of SIRT1 induced by 17beta-estradiol (17beta-E2) could promote autophagy and inhibit apoptosis in osteoblasts via the AMPK-mTOR and FOXO3a pathways, respectively. The study found that 17beta-E2 (10(-6) M) administration …
This study aimed to assess whether the up-regulation of SIRT1 induced by 17beta-estradiol (17beta-E2) could promote autophagy and inhibit ap …
Eight Metagenome-Assembled Genomes Provide Evidence for Microbial Adaptation in 20,000- to 1,000,000-Year-Old Siberian Permafrost.
Sipes K, Almatari A, Eddie A, Williams D, Spirina E, Rivkina E, Liang R, Onstott TC, Vishnivetskaya TA, Lloyd KG. Sipes K, et al. Appl Environ Microbiol. 2021 Sep 10;87(19):e0097221. doi: 10.1128/AEM.00972-21. Epub 2021 Sep 10. Appl Environ Microbiol. 2021. PMID: 34288700 Free PMC article.
Thirty-three metagenome-assembled genomes (MAGs) were obtained from six depths (3.5 m to 20 m) of freshly cored permafrost from the Siberian Kolyma-Indigirka Lowland region. ...
Thirty-three metagenome-assembled genomes (MAGs) were obtained from six depths (3.5 m to 20 m) of freshly cored permafrost fro …
SYNTHESIS OF SOME NOVEL THIOPHENE ANALOGUES AS POTENTIAL ANTICANCER AGENTS.
Almatari AS, Saeed A, Abdel-Ghani GE, Abdullah MMS, Al-Lohedan HA, Abdel-Latif E, El-Demerdash A. Almatari AS, et al. Chem Biodivers. 2024 Mar 11:e202400313. doi: 10.1002/cbdv.202400313. Online ahead of print. Chem Biodivers. 2024. PMID: 38467571
The amino-thiophene derivative 15b exhibited an increased growth inhibition of A2780, and A2780CP with IC50 values 120.17, and 100.15 M, respectively compared to Sorafenib with IC50 values 7.50.54 and 9.40.14. ...
The amino-thiophene derivative 15b exhibited an increased growth inhibition of A2780, and A2780CP with IC50 values 120.17, and 100.15 M …