Germline biomarkers predict toxicity to anti-PD1/PDL1 checkpoint therapy.
Weidhaas J, Marco N, Scheffler AW, Kalbasi A, Wilenius K, Rietdorf E, Gill J, Heilig M, Desler C, Chin RK, Kaprealian T, McCloskey S, Raldow A, Raja NP, Kesari S, Carrillo J, Drakaki A, Scholz M, Telesca D.
Weidhaas J, et al.
J Immunother Cancer. 2022 Feb;10(2):e003625. doi: 10.1136/jitc-2021-003625.
J Immunother Cancer. 2022.
PMID: 35115362
Free PMC article.
METHODS: MicroRNA pathway variants were evaluated for an association with grade 2 or higher toxicity using four classifiers on 62 patients with melanoma, and then the panel's performance was validated on 99 patients with other cancer types. Trained classifiers included classifica …
METHODS: MicroRNA pathway variants were evaluated for an association with grade 2 or higher toxicity using four classifiers on 62 patients w …