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Dynamic IgG antibody response to immunodominant antigens of M. tuberculosis for active TB diagnosis in high endemic settings.
Pathakumari B, Prabhavathi M, Anbarasu D, Paramanandhan P, Raja A. Pathakumari B, et al. Clin Chim Acta. 2016 Oct 1;461:25-33. doi: 10.1016/j.cca.2016.06.033. Epub 2016 Jun 28. Clin Chim Acta. 2016. PMID: 27370403
Hence, one of the possibilities is identification of Mycobacterium tuberculosis specific antibodies in infected serum by using specific antigens. METHODS: We tested 10 recombinant M. tuberculosis antigens to evaluate IgG levels among Healthy control subjects (HCS), Healthy …
Hence, one of the possibilities is identification of Mycobacterium tuberculosis specific antibodies in infected serum by using specific anti …
Isolation of Potential Compound from the Leaves of Elytraria acaulis and Evaluating Its Therapeutic Properties Using In Vitro Studies Against Ovarian Cancer.
Priya P, Anbarasu M, Christina VS, Majeed SA, Sivamurugan V, Sundaram RL. Priya P, et al. Appl Biochem Biotechnol. 2022 Dec;194(12):5607-5626. doi: 10.1007/s12010-022-04048-7. Epub 2022 Jul 7. Appl Biochem Biotechnol. 2022. PMID: 35796948
In the cell cycle analysis, the isolated compound induced a significant increase in the percentage of cells in G0/G1 phase and a decrease in the percentage of cells in the S phase and G2-M phase of the PA 1 cell lines. The cell cycle arrest induced by the isolated compound …
In the cell cycle analysis, the isolated compound induced a significant increase in the percentage of cells in G0/G1 phase and a decrease in …
Genome sequencing and molecular characterisation of XDR Acinetobacter baumannii reveal complexities in resistance: Novel combination of sulbactam-durlobactam holds promise for therapeutic intervention.
Naha A, Vijayakumar S, Lal B, Shankar BA, Chandran S, Ramaiah S, Veeraraghavan B, Anbarasu A. Naha A, et al. J Cell Biochem. 2021 Dec;122(12):1946-1957. doi: 10.1002/jcb.30156. Epub 2021 Oct 1. J Cell Biochem. 2021. PMID: 34597421
Furthermore, higher binding affinities and low inhibition constants were noted in OXA23-DUR (-7.36 kcal/mol; 4.01 M), OXA58-DUR (-6.44 kcal/mol; 19.07 M), and NDM-DUR (-6.82 kcal/mol; 10.01 M) complexes when compared with the conventional drugs avibactam and …
Furthermore, higher binding affinities and low inhibition constants were noted in OXA23-DUR (-7.36 kcal/mol; 4.01 M), OXA58-DUR (-6.4 …
Network metrics, structural dynamics and density functional theory calculations identified a novel Ursodeoxycholic Acid derivative against therapeutic target Parkin for Parkinson's disease.
Naha A, Banerjee S, Debroy R, Basu S, Ashok G, Priyamvada P, Kumar H, Preethi AR, Singh H, Anbarasu A, Ramaiah S. Naha A, et al. Comput Struct Biotechnol J. 2022 Aug 10;20:4271-4287. doi: 10.1016/j.csbj.2022.08.017. eCollection 2022. Comput Struct Biotechnol J. 2022. PMID: 36051887 Free PMC article.
Molecule-258 (ZINC5022267) was selected as a potent candidate based on pharmacokinetic profiles, Density Functional Theory (DFT) energy calculations (deltaE = 6.93 eV) and high binding affinity (Binding energy = -6.57 0.1 kcal/mol; Inhibition constant = 15.35 M) against Pa …
Molecule-258 (ZINC5022267) was selected as a potent candidate based on pharmacokinetic profiles, Density Functional Theory (DFT) energy calc …
Essentiality Assessment of Cysteinyl and Lysyl-tRNA Synthetases of Mycobacterium smegmatis.
Ravishankar S, Ambady A, Swetha RG, Anbarasu A, Ramaiah S, Sambandamurthy VK. Ravishankar S, et al. PLoS One. 2016 Jan 21;11(1):e0147188. doi: 10.1371/journal.pone.0147188. eCollection 2016. PLoS One. 2016. PMID: 26794499 Free PMC article.
Herein, we describe sequence and structural analysis of the additional aminoacyl-tRNA synthetase genes found in M. smegmatis. Characterization of conditional expression strains of Cysteinyl and Lysyl-tRNA synthetases generated in M. smegmatis revealed that the canon …
Herein, we describe sequence and structural analysis of the additional aminoacyl-tRNA synthetase genes found in M. smegmatis. Charact …
Transcriptional expression of secondary resistance genes ccdB and repA2 is enhanced in presence of cephalosporin and carbapenem in Escherichia coli.
Baishya S, Deshamukhya C, Wangkheimayum J, Das BJ, Anbarasu A, Talukdar AD, Bhattacharjee A, Choudhury MD. Baishya S, et al. BMC Microbiol. 2021 Mar 9;21(1):79. doi: 10.1186/s12866-021-02136-y. BMC Microbiol. 2021. PMID: 33750290 Free PMC article.
In this context influential genes belonging to secondary resistome that act as helper to the primary resistance genes like bla(NDM) and bla(CTX-M) in aggravating beta-lactam resistance were selected from an earlier reported in silico study. ...CONCLUSION: SRGs repA2 and cc …
In this context influential genes belonging to secondary resistome that act as helper to the primary resistance genes like bla(NDM) and bla( …
Computational study of the piperidine and FtsZ interaction in Salmonella Typhi: implications for disrupting cell division machinery.
Kumar H, Manoharan A, Anbarasu A, Ramaiah S. Kumar H, et al. J Biomol Struct Dyn. 2024 Feb 7:1-14. doi: 10.1080/07391102.2024.2314272. Online ahead of print. J Biomol Struct Dyn. 2024. PMID: 38321931
The 400 isoforms of piperidine analogues were curated, among them potent compound ZINC000000005416 found to possess high binding affinity (-8.49 kcal/mol) and low dissociation constant (0.597 M). The highest binding affinity shown by ZINC000000005416 was validated by hydro …
The 400 isoforms of piperidine analogues were curated, among them potent compound ZINC000000005416 found to possess high binding affinity (- …
22 results