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Amyloid precursor protein 96-110 and beta-amyloid 1-42 elicit developmental anomalies in sea urchin embryos and larvae that are alleviated by neurotransmitter analogs for acetylcholine, serotonin and cannabinoids.
Buznikov GA, Nikitina LA, Seidler FJ, Slotkin TA, Bezuglov VV, Milosević I, Lazarević L, Rogac L, Ruzdijić S, Rakić LM. Buznikov GA, et al. Among authors: nikitina la. Neurotoxicol Teratol. 2008 Nov-Dec;30(6):503-9. doi: 10.1016/j.ntt.2008.05.003. Epub 2008 May 16. Neurotoxicol Teratol. 2008. PMID: 18565728 Free PMC article.
The sea urchin embryo, an invertebrate model for mammalian developmental neurotoxicity, reveals multiple neurotransmitter mechanisms for effects of chlorpyrifos: therapeutic interventions and a comparison with the monoamine depleter, reserpine.
Buznikov GA, Nikitina LA, Rakić LM, Milosević I, Bezuglov VV, Lauder JM, Slotkin TA. Buznikov GA, et al. Among authors: nikitina la. Brain Res Bull. 2007 Sep 28;74(4):221-31. doi: 10.1016/j.brainresbull.2007.06.012. Epub 2007 Jul 6. Brain Res Bull. 2007. PMID: 17720543 Free PMC article.