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PERK is a critical metabolic hub for immunosuppressive function in macrophages.
Raines LN, Zhao H, Wang Y, Chen HY, Gallart-Ayala H, Hsueh PC, Cao W, Koh Y, Alamonte-Loya A, Liu PS, Ivanisevic J, Lio CJ, Ho PC, Huang SC. Raines LN, et al. Nat Immunol. 2022 Mar;23(3):431-445. doi: 10.1038/s41590-022-01145-x. Epub 2022 Feb 28. Nat Immunol. 2022. PMID: 35228694 Free PMC article.
Tumor-induced reshuffling of lipid composition on the endoplasmic reticulum membrane sustains macrophage survival and pro-tumorigenic activity.
Di Conza G, Tsai CH, Gallart-Ayala H, Yu YR, Franco F, Zaffalon L, Xie X, Li X, Xiao Z, Raines LN, Falquet M, Jalil A, Locasale JW, Percipalle P, Masson D, Huang SC, Martinon F, Ivanisevic J, Ho PC. Di Conza G, et al. Among authors: raines ln. Nat Immunol. 2021 Nov;22(11):1403-1415. doi: 10.1038/s41590-021-01047-4. Epub 2021 Oct 22. Nat Immunol. 2021. PMID: 34686867 Free PMC article.
Is glucose the scapegoat for tumor evasion?
Raines LN, Huang SC. Raines LN, et al. Cancer Cell. 2021 Jul 12;39(7):907-909. doi: 10.1016/j.ccell.2021.06.006. Cancer Cell. 2021. PMID: 34256906 Free article.
Intrabone transplantation of CD34+ cells with optimized delivery does not enhance engraftment in a rhesus macaque model.
Stringaris K, Hoyt RF, Davidson-Moncada JK, Pantin JM, Tisdale JF, Uchida N, Raines LN, Reger R, Sato N, Dunbar CE, Hunt TJ, Clevenger RR, Krouse A, Metzger ME, Bonifacino AC, Telford W, Choyke PL, Engels T, Donahue RE, Childs RW. Stringaris K, et al. Among authors: raines ln. Blood Adv. 2020 Dec 22;4(24):6148-6156. doi: 10.1182/bloodadvances.2020003040. Blood Adv. 2020. PMID: 33351110 Free PMC article.