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Page 1
Synthesis and Antimycobacterial Evaluation of N-(4-(Benzyloxy)benzyl)-4-aminoquinolines.
Grams ES, Silva Ramos A, Neves Muniz M, Rambo RS, Alberton Perelló M, Sperotto N, Calle González L, Duarte LS, Galina L, Silva Dadda A, Arraché Gonçalves G, Valim Bizarro C, Basso LA, Machado P. Grams ES, et al. Among authors: galina l. Molecules. 2022 Apr 15;27(8):2556. doi: 10.3390/molecules27082556. Molecules. 2022. PMID: 35458755 Free PMC article.
Antitubercular Activity of Novel 2-(Quinoline-4-yloxy)acetamides with Improved Drug-Like Properties.
Borsoi AF, Alice LM, Sperotto N, Ramos AS, Abbadi BL, Macchi Hopf FS, Silva Dadda AD, Rambo RS, Madeira Silva RB, Paz JD, Pissinate K, Muniz MN, Neves CE, Galina L, González LC, Perelló MA, de Matos Czeczot A, Leyser M, de Oliveira SD, de Araújo Lock G, de Araújo BV, Costa TD, Bizarro CV, Basso LA, Machado P. Borsoi AF, et al. Among authors: galina l. ACS Med Chem Lett. 2022 Jul 21;13(8):1337-1344. doi: 10.1021/acsmedchemlett.2c00254. eCollection 2022 Aug 11. ACS Med Chem Lett. 2022. PMID: 35978694 Free PMC article.
Exploring Scaffold Hopping for Novel 2-(Quinolin-4-yloxy)acetamides with Enhanced Antimycobacterial Activity.
Borsoi AF, Silva Ramos A, Sperotto N, Abbadi BL, Souza Macchi Hopf F, da Silva Dadda A, Scheibler Rambo R, Neves Muniz M, Delgado Paz J, Silveira Grams E, Fries da Silva F, Pissinate K, Galina L, Calle González L, Silva Duarte L, Alberton Perelló M, de Matos Czeczot A, Bizarro CV, Basso LA, Machado P. Borsoi AF, et al. Among authors: galina l. ACS Med Chem Lett. 2024 Mar 11;15(4):493-500. doi: 10.1021/acsmedchemlett.3c00570. eCollection 2024 Apr 11. ACS Med Chem Lett. 2024. PMID: 38628799
EPSP Synthase-Depleted Cells Are Aromatic Amino Acid Auxotrophs in Mycobacterium smegmatis.
Duque-Villegas MA, Abbadi BL, Romero PR, Matter LB, Galina L, Dalberto PF, Rodrigues-Junior VDS, Ducati RG, Roth CD, Rambo RS, de Souza EV, Perello MA, Morbidoni HR, Machado P, Basso LA, Bizarro CV. Duque-Villegas MA, et al. Among authors: galina l. Microbiol Spectr. 2021 Dec 22;9(3):e0000921. doi: 10.1128/Spectrum.00009-21. Epub 2021 Dec 22. Microbiol Spectr. 2021. PMID: 34937164 Free PMC article.
Inhibitory activity of pentacyano(isoniazid)ferrate(II), IQG-607, against promastigotes and amastigotes forms of Leishmania braziliensis.
Amorim CF, Galina L, Carvalho NB, Sperotto NDM, Pissinate K, Machado P, Campos MM, Basso LA, Rodrigues-Junior VS, Carvalho EM, Santos DS. Amorim CF, et al. Among authors: galina l. PLoS One. 2017 Dec 27;12(12):e0190294. doi: 10.1371/journal.pone.0190294. eCollection 2017. PLoS One. 2017. PMID: 29281707 Free PMC article.
Novel 4-aminoquinolines: Synthesis, inhibition of the Mycobacterium tuberculosis enoyl-acyl carrier protein reductase, antitubercular activity, SAR, and preclinical evaluation.
Paz JD, Denise de Moura Sperotto N, Ramos AS, Pissinate K, da Silva Rodrigues Junior V, Abbadi BL, Borsoi AF, Rambo RS, Corso Minotto AC, da Silva Dadda A, Galina L, Macchi Hopf FS, Muniz MN, Borges Martinelli LK, Roth CD, Madeira Silva RB, Perelló MA, de Matos Czeczot A, Neves CE, Duarte LS, Leyser M, Dias de Oliveira S, Bizarro CV, Machado P, Basso LA. Paz JD, et al. Among authors: galina l. Eur J Med Chem. 2023 Jan 5;245(Pt 1):114908. doi: 10.1016/j.ejmech.2022.114908. Epub 2022 Nov 18. Eur J Med Chem. 2023. PMID: 36435016