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Kinin Receptors Sensitize TRPV4 Channel and Induce Mechanical Hyperalgesia: Relevance to Paclitaxel-Induced Peripheral Neuropathy in Mice.
Costa R, Bicca MA, Manjavachi MN, Segat GC, Dias FC, Fernandes ES, Calixto JB. Costa R, et al. Mol Neurobiol. 2018 Mar;55(3):2150-2161. doi: 10.1007/s12035-017-0475-9. Epub 2017 Mar 10. Mol Neurobiol. 2018. PMID: 28283888
Kinin B(1) (B(1)R) and B(2) receptors (B(2)R) and the transient receptor potential vanilloid 4 (TRPV4) channel are known to play a critical role in the peripheral neuropathy induced by paclitaxel (PTX) in rodents. ...Herein, we investigated whether kinins sensitize …
Kinin B(1) (B(1)R) and B(2) receptors (B(2)R) and the transient receptor potential vanilloid 4 (TRPV4) channel are known to pl …
The kinin B1 and B2 receptors and TNFR1/p55 axis on neuropathic pain in the mouse brachial plexus.
Quintão NLM, Rocha LW, da Silva GF, Paszcuk AF, Manjavachi MN, Bento AF, da Silva KABS, Campos MM, Calixto JB. Quintão NLM, et al. Inflammopharmacology. 2019 Jun;27(3):573-586. doi: 10.1007/s10787-019-00578-5. Epub 2019 Feb 28. Inflammopharmacology. 2019. PMID: 30820720
The connection between TNF1/p55 and kinin B(1) and B(2) receptors (B(1)R and B(2)R) was confirmed using both knockout mice and mRNAs quantification in the injected nerve, DRG and spinal cord. The treatment with the B(2)R antagonist HOE 140 or with B(1)R …
The connection between TNF1/p55 and kinin B(1) and B(2) receptors (B(1)R and B(2)R) was confirmed using both knockout mice and …