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Page 1
Exploring association of melanoma-specific Bcl-xL with tumor immune microenvironment.
Lucianò AM, Di Martile M, Pérez-Oliva AB, Di Caprio M, Foddai ML, Buglioni S, Mulero V, Del Bufalo D. Lucianò AM, et al. J Exp Clin Cancer Res. 2023 Jul 24;42(1):178. doi: 10.1186/s13046-023-02735-9. J Exp Clin Cancer Res. 2023. PMID: 37488586 Free PMC article.
Mouse and zebrafish models were used to evaluate the ability of melanoma cells to recruit and polarize macrophages in vivo. RESULTS: We demonstrated that melanoma cells overexpressing Bcl-xL recruit macrophages at the tumor site and induce a M2 phenotype. ...
Mouse and zebrafish models were used to evaluate the ability of melanoma cells to recruit and polarize macrophages in vivo. RESULTS: …
Gene-mapping study of extremes of cerebral small vessel disease reveals TRIM47 as a strong candidate.
Mishra A, Duplaà C, Vojinovic D, Suzuki H, Sargurupremraj M, Zilhão NR, Li S, Bartz TM, Jian X, Zhao W, Hofer E, Wittfeld K, Harris SE, van der Auwera-Palitschka S, Luciano M, Bis JC, Adams HHH, Satizabal CL, Gottesman RF, Gampawar PG, Bülow R, Weiss S, Yu M, Bastin ME, Lopez OL, Vernooij MW, Beiser AS, Völker U, Kacprowski T, Soumare A, Smith JA, Knopman DS, Morris Z, Zhu Y, Rotter JI, Dufouil C, Valdés Hernández M, Muñoz Maniega S, Lathrop M, Boerwinkle E, Schmidt R, Ihara M, Mazoyer B, Yang Q, Joutel A, Tournier-Lasserve E, Launer LJ, Deary IJ, Mosley TH, Amouyel P, DeCarli CS, Psaty BM, Tzourio C, Kardia SLR, Grabe HJ, Teumer A, van Duijn CM, Schmidt H, Wardlaw JM, Ikram MA, Fornage M, Gudnason V, Seshadri S, Matthews PM, Longstreth WT, Couffinhal T, Debette S. Mishra A, et al. Brain. 2022 Jun 30;145(6):1992-2007. doi: 10.1093/brain/awab432. Brain. 2022. PMID: 35511193 Free PMC article.
Overall, our comprehensive gene-mapping study and preliminary functional evaluation suggests a putative role of TRIM47 in the pathophysiology of cerebral small vessel disease, making it an important candidate for extensive in vivo explorations and future translational work …
Overall, our comprehensive gene-mapping study and preliminary functional evaluation suggests a putative role of TRIM47 in the pathophysiolog …
Current status and perspectives in split liver transplantation.
Lauterio A, Di Sandro S, Concone G, De Carlis R, Giacomoni A, De Carlis L. Lauterio A, et al. World J Gastroenterol. 2015 Oct 21;21(39):11003-15. doi: 10.3748/wjg.v21.i39.11003. World J Gastroenterol. 2015. PMID: 26494957 Free PMC article. Review.
β2-AR inhibition enhances EGFR antibody efficacy hampering the oxidative stress response machinery.
Del Vecchio V, Mele L, Panda SK, Sanchez-Pajares IR, Mosca L, Tirino V, Barbieri M, Bruzzese F, Luciano A, Marino FZ, Accardo M, Nicoletti GF, Papaccio G, Barbieri A, Desiderio V. Del Vecchio V, et al. Cell Death Dis. 2023 Sep 19;14(9):613. doi: 10.1038/s41419-023-06129-9. Cell Death Dis. 2023. PMID: 37723219 Free PMC article.
Our findings highlighted for the first time, in a pre-clinical in vivo model, the efficacy of the beta2-ARs inhibition in the treatment of the HNSCC, remarkably in combination with CTX, which is the standard of care for unresectable HNSCC....
Our findings highlighted for the first time, in a pre-clinical in vivo model, the efficacy of the beta2-ARs inhibition in the treatme …
Engineering 3D-Printed Advanced Healthcare Materials for Periprosthetic Joint Infections.
Yuste I, Luciano FC, Anaya BJ, Sanz-Ruiz P, Ribed-Sánchez A, González-Burgos E, Serrano DR. Yuste I, et al. Antibiotics (Basel). 2023 Jul 25;12(8):1229. doi: 10.3390/antibiotics12081229. Antibiotics (Basel). 2023. PMID: 37627649 Free PMC article. Review.
Although these novel treatments are demonstrating promising results, in vivo studies and clinical trials are required for their translation from the bench to the market....
Although these novel treatments are demonstrating promising results, in vivo studies and clinical trials are required for their trans …
Mimicking bone microenvironment: 2D and 3D in vitro models of human osteoblasts.
Yuste I, Luciano FC, González-Burgos E, Lalatsa A, Serrano DR. Yuste I, et al. Pharmacol Res. 2021 Jul;169:105626. doi: 10.1016/j.phrs.2021.105626. Epub 2021 Apr 21. Pharmacol Res. 2021. PMID: 33892092 Free article. Review.
Understanding the in vitro biology and behavior of human osteoblasts is crucial for developing research models that reproduce closely the bone structure, its functions, and the cell-cell and cell-matrix interactions that occurs in vivo. Mimicking bone microenvironment is c …
Understanding the in vitro biology and behavior of human osteoblasts is crucial for developing research models that reproduce closely the bo …
1,2,4-Thiadiazolidin-3,5-diones as novel hydrogen sulfide donors.
Severino B, Corvino A, Fiorino F, Luciano P, Frecentese F, Magli E, Saccone I, Di Vaio P, Citi V, Calderone V, Servillo L, Casale R, Cirino G, Vellecco V, Bucci M, Perissutti E, Santagada V, Caliendo G. Severino B, et al. Eur J Med Chem. 2018 Jan 1;143:1677-1686. doi: 10.1016/j.ejmech.2017.10.068. Epub 2017 Nov 11. Eur J Med Chem. 2018. PMID: 29133036
One of the major problem is the limited availability of chemicals that ensure a controlled release of H(2)S in vitro as well in vivo. Aiming to obtain novel H(2)S donors, whose release properties could be appropriately modulated, we have synthesized a series of 1,2,4-thiad …
One of the major problem is the limited availability of chemicals that ensure a controlled release of H(2)S in vitro as well in vivo. …
Targeting acute myeloid leukemia dependency on VCP-mediated DNA repair through a selective second-generation small-molecule inhibitor.
Roux B, Vaganay C, Vargas JD, Alexe G, Benaksas C, Pardieu B, Fenouille N, Ellegast JM, Malolepsza E, Ling F, Sodaro G, Ross L, Pikman Y, Conway AS, Tang Y, Wu T, Anderson DJ, Le Moigne R, Zhou HJ, Luciano F, Hartigan CR, Galinsky I, DeAngelo DJ, Stone RM, Auberger P, Schenone M, Carr SA, Guirouilh-Barbat J, Lopez B, Khaled M, Lage K, Hermine O, Hemann MT, Puissant A, Stegmaier K, Benajiba L. Roux B, et al. Sci Transl Med. 2021 Mar 31;13(587):eabg1168. doi: 10.1126/scitranslmed.abg1168. Sci Transl Med. 2021. PMID: 33790022 Free PMC article.
Such adaptations can confer intrinsic vulnerabilities, enabling the selective targeting of cancer cells. Through a pooled in vivo short hairpin RNA (shRNA) screen, we identified the adenosine triphosphatase associated with diverse cellular activities (AAA-ATPase) valosin-c …
Such adaptations can confer intrinsic vulnerabilities, enabling the selective targeting of cancer cells. Through a pooled in vivo sho …
Targeted multicolor in vivo imaging over 1,000 nm enabled by nonamethine cyanines.
Bandi VG, Luciano MP, Saccomano M, Patel NL, Bischof TS, Lingg JGP, Tsrunchev PT, Nix MN, Ruehle B, Sanders C, Riffle L, Robinson CM, Difilippantonio S, Kalen JD, Resch-Genger U, Ivanic J, Bruns OT, Schnermann MJ. Bandi VG, et al. Nat Methods. 2022 Mar;19(3):353-358. doi: 10.1038/s41592-022-01394-6. Epub 2022 Feb 28. Nat Methods. 2022. PMID: 35228725
Recent progress has shown that using wavelengths between 1,000 and 2,000 nm, referred to as the shortwave-infrared or near-infrared (NIR)-II range, can enable high-resolution in vivo imaging at depths not possible with conventional optical wavelengths. ...Using rational de …
Recent progress has shown that using wavelengths between 1,000 and 2,000 nm, referred to as the shortwave-infrared or near-infrared (NIR)-II …
Nutritive value of fermented soybean grains for ruminants.
de Carvalho LB, da Costa AC, Neta BSM, Fonseca ASR, Vieira KPN, de Abreu MLC, E Pedreira BC, Galati RL, Guerra WD, Cabral LDS. de Carvalho LB, et al. Trop Anim Health Prod. 2023 Nov 24;55(6):420. doi: 10.1007/s11250-023-03813-y. Trop Anim Health Prod. 2023. PMID: 37999775
Fermented soybean grain (FSBG) is considered improper to use as a protein source in animal nutrition, since it is assumed that defects cause changes on its chemical composition and favor mycotoxins production, but chemical composition data does not support this theory and in v …
Fermented soybean grain (FSBG) is considered improper to use as a protein source in animal nutrition, since it is assumed that defects cause …
44 results