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High-Throughput Screening Reveals New Glutaminase Inhibitor Molecules.
E Costa RK, Rodrigues CT, H Campos JC, Paradela LS, Dias MM, Novaes da Silva B, de Valega Negrao CVZ, Gonçalves KA, Ascenção CFR, Adamoski D, Mercaldi GF, Bastos ACS, Batista FAH, Figueira AC, Cordeiro AT, Ambrosio ALB, Guido RVC, Dias SMG. E Costa RK, et al. Among authors: paradela ls. ACS Pharmacol Transl Sci. 2021 Dec 1;4(6):1849-1866. doi: 10.1021/acsptsci.1c00226. eCollection 2021 Dec 10. ACS Pharmacol Transl Sci. 2021. PMID: 34927015 Free PMC article.
Multiple unbiased approaches identify oxidosqualene cyclase as the molecular target of a promising anti-leishmanial.
Paradela LS, Wall RJ, Carvalho S, Chemi G, Corpas-Lopez V, Moynihan E, Bello D, Patterson S, Güther MLS, Fairlamb AH, Ferguson MAJ, Zuccotto F, Martin J, Gilbert IH, Wyllie S. Paradela LS, et al. Cell Chem Biol. 2021 May 20;28(5):711-721.e8. doi: 10.1016/j.chembiol.2021.02.008. Epub 2021 Mar 9. Cell Chem Biol. 2021. PMID: 33691122 Free PMC article.
Chemical Elicitors Induce Rare Bioactive Secondary Metabolites in Deep-Sea Bacteria under Laboratory Conditions.
de Felício R, Ballone P, Bazzano CF, Alves LFG, Sigrist R, Infante GP, Niero H, Rodrigues-Costa F, Fernandes AZN, Tonon LAC, Paradela LS, Costa RKE, Dias SMG, Dessen A, Telles GP, da Silva MAC, Lima AOS, Trivella DBB. de Felício R, et al. Among authors: paradela ls. Metabolites. 2021 Feb 12;11(2):107. doi: 10.3390/metabo11020107. Metabolites. 2021. PMID: 33673148 Free PMC article.