Pancytopenia in a Case of Aplastic Anaemia/Paroxysmal Nocturnal Haemoglobinuria Unmasked by SARS-CoV-2 Infection: A Case Report

Medicina (Kaunas). 2022 Sep 15;58(9):1282. doi: 10.3390/medicina58091282.

Abstract

During an acute SARS-CoV-2 infection, a diagnosis of Aplastic Anaemia associated with Paroxysmal Nocturnal Haemoglobinuria (AA/PNH) was made in a 78-year-old woman who had presented to the emergency department with severe pancytopenia. It is possible that she had subclinical AA/PNH that was unmasked during the acute COVID-19 infection, but we can also suspect a direct role of the virus in the pathogenesis of the disease, or we can hypothesize that COVID-19 infection changed the phosphatidylinositol glycan class A (PIGA) gene pathway.

Keywords: COVID-19; PIGA gene; Paroxysmal Nocturnal Haemoglobinuria; aplastic anaemia.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Anemia, Aplastic* / complications
  • Anemia, Aplastic* / diagnosis
  • Anemia, Aplastic* / genetics
  • COVID-19* / complications
  • Female
  • Glycosylphosphatidylinositols
  • Hemoglobinuria, Paroxysmal* / complications
  • Hemoglobinuria, Paroxysmal* / diagnosis
  • Humans
  • Pancytopenia* / complications
  • SARS-CoV-2

Substances

  • Glycosylphosphatidylinositols

Grants and funding

This research received no external funding.