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The small molecule GAT1508 activates brain-specific GIRK1/2 channel heteromers and facilitates conditioned fear extinction in rodents.
Xu Y, Cantwell L, Molosh AI, Plant LD, Gazgalis D, Fitz SD, Dustrude ET, Yang Y, Kawano T, Garai S, Noujaim SF, Shekhar A, Logothetis DE, Thakur GA. Xu Y, et al. Among authors: cantwell l. J Biol Chem. 2020 Mar 13;295(11):3614-3634. doi: 10.1074/jbc.RA119.011527. Epub 2020 Jan 17. J Biol Chem. 2020. PMID: 31953327 Free PMC article.
Heteromeric Neuronal Nicotinic Acetylcholine Receptors with Mutant β Subunits Acquire Sensitivity to α7-Selective Positive Allosteric Modulators.
Stokes C, Garai S, Kulkarni AR, Cantwell LN, Noviello CM, Hibbs RE, Horenstein NA, Abboud KA, Thakur GA, Papke RL. Stokes C, et al. Among authors: cantwell ln. J Pharmacol Exp Ther. 2019 Aug;370(2):252-268. doi: 10.1124/jpet.119.259499. Epub 2019 Jun 7. J Pharmacol Exp Ther. 2019. PMID: 31175218 Free PMC article.
Dose-dependent effects of GAT107, a novel allosteric agonist-positive allosteric modulator (ago-PAM) for the α7 nicotinic cholinergic receptor: a BOLD phMRI and connectivity study on awake rats.
Brems BM, Sullivan EE, Connolly JG, Zhang J, Chang A, Ortiz R, Cantwell L, Kulkarni P, Thakur GA, Ferris CF. Brems BM, et al. Among authors: cantwell l. Front Neurosci. 2023 Jun 23;17:1196786. doi: 10.3389/fnins.2023.1196786. eCollection 2023. Front Neurosci. 2023. PMID: 37424993 Free PMC article.
The α7 nicotinic receptor silent agonist R-47 prevents and reverses paclitaxel-induced peripheral neuropathy in mice without tolerance or altering nicotine reward and withdrawal.
Toma W, Kyte SL, Bagdas D, Jackson A, Meade JA, Rahman F, Chen ZJ, Del Fabbro E, Cantwell L, Kulkarni A, Thakur GA, Papke RL, Bigbee JW, Gewirtz DA, Damaj MI. Toma W, et al. Among authors: cantwell l. Exp Neurol. 2019 Oct;320:113010. doi: 10.1016/j.expneurol.2019.113010. Epub 2019 Jul 9. Exp Neurol. 2019. PMID: 31299179 Free PMC article.
11 results