Abstract
The study of the secondary metabolites contained in the organic extract of Caribbean sponge Smenospongia aurea led to the isolation of smenothiazole A (3) and B (4), hybrid peptide/polyketide compounds. Assays performed using four solid tumor cell lines showed that smenothiazoles exert a potent cytotoxic activity at nanomolar levels, with selectivity over ovarian cancer cells and a pro-apoptotic mechanism.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Apoptosis / drug effects
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Cell Line, Tumor / drug effects
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Chromatography, High Pressure Liquid
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Humans
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MCF-7 Cells / drug effects
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Molecular Structure
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Porifera / chemistry*
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Thiazoles / chemistry
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Thiazoles / isolation & purification*
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Thiazoles / pharmacology
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Valine / analogs & derivatives*
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Valine / chemistry
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Valine / isolation & purification
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Valine / pharmacology
Substances
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Antineoplastic Agents
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Thiazoles
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smenothiazole A
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smenothiazole B
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Valine