Isolation and assessment of the in vitro anti-tumor activity of smenothiazole A and B, chlorinated thiazole-containing peptide/polyketides from the Caribbean sponge, Smenospongia aurea

Mar Drugs. 2015 Jan 16;13(1):444-59. doi: 10.3390/md13010444.

Abstract

The study of the secondary metabolites contained in the organic extract of Caribbean sponge Smenospongia aurea led to the isolation of smenothiazole A (3) and B (4), hybrid peptide/polyketide compounds. Assays performed using four solid tumor cell lines showed that smenothiazoles exert a potent cytotoxic activity at nanomolar levels, with selectivity over ovarian cancer cells and a pro-apoptotic mechanism.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / pharmacology
  • Apoptosis / drug effects
  • Cell Line, Tumor / drug effects
  • Chromatography, High Pressure Liquid
  • Humans
  • MCF-7 Cells / drug effects
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Molecular Structure
  • Porifera / chemistry*
  • Thiazoles / chemistry
  • Thiazoles / isolation & purification*
  • Thiazoles / pharmacology
  • Valine / analogs & derivatives*
  • Valine / chemistry
  • Valine / isolation & purification
  • Valine / pharmacology

Substances

  • Antineoplastic Agents
  • Thiazoles
  • smenothiazole A
  • smenothiazole B
  • Valine