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Kaposi Sarcoma Herpes Virus (KSHV) infection inhibits macrophage formation and survival by counteracting Macrophage Colony-Stimulating Factor (M-CSF)-induced increase of Reactive Oxygen Species (ROS), c-Jun N-terminal kinase (JNK) phosphorylation and autophagy.
Gilardini Montani MS, Falcinelli L, Santarelli R, Romeo MA, Granato M, Faggioni A, Cirone M. Gilardini Montani MS, et al. Among authors: falcinelli l. Int J Biochem Cell Biol. 2019 Sep;114:105560. doi: 10.1016/j.biocel.2019.06.008. Epub 2019 Jun 17. Int J Biochem Cell Biol. 2019. PMID: 31220583
KSHV infection skews macrophage polarisation towards M2-like/TAM and activates Ire1 α-XBP1 axis up-regulating pro-tumorigenic cytokine release and PD-L1 expression.
Gilardini Montani MS, Falcinelli L, Santarelli R, Granato M, Romeo MA, Cecere N, Gonnella R, D'Orazi G, Faggioni A, Cirone M. Gilardini Montani MS, et al. Among authors: falcinelli l. Br J Cancer. 2020 Jul;123(2):298-306. doi: 10.1038/s41416-020-0872-0. Epub 2020 May 18. Br J Cancer. 2020. PMID: 32418990 Free PMC article.
Mutant p53, Stabilized by Its Interplay with HSP90, Activates a Positive Feed-Back Loop Between NRF2 and p62 that Induces Chemo-Resistance to Apigenin in Pancreatic Cancer Cells.
Gilardini Montani MS, Cecere N, Granato M, Romeo MA, Falcinelli L, Ciciarelli U, D'Orazi G, Faggioni A, Cirone M. Gilardini Montani MS, et al. Among authors: falcinelli l. Cancers (Basel). 2019 May 22;11(5):703. doi: 10.3390/cancers11050703. Cancers (Basel). 2019. PMID: 31121848 Free PMC article.