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The RNA-binding protein QKI governs a muscle-specific alternative splicing program that shapes the contractile function of cardiomyocytes.
Montañés-Agudo P, Aufiero S, Schepers EN, van der Made I, Cócera-Ortega L, Ernault AC, Richard S, Kuster DWD, Christoffels VM, Pinto YM, Creemers EE. Montañés-Agudo P, et al. Among authors: cocera ortega l. Cardiovasc Res. 2023 May 22;119(5):1161-1174. doi: 10.1093/cvr/cvad007. Cardiovasc Res. 2023. PMID: 36627242 Free PMC article.
Toward Biological Pacing by Cellular Delivery of Hcn2/SkM1.
Végh AMD, Verkerk AO, Cócera Ortega L, Wang J, Geerts D, Klerk M, Lodder K, Nobel R, Tijsen AJ, Devalla HD, Christoffels VM, Medina-Ramírez M, Smits AM, Tan HL, Wilders R, Goumans MJTH, Boink GJJ. Végh AMD, et al. Among authors: cocera ortega l. Front Physiol. 2021 Jan 6;11:588679. doi: 10.3389/fphys.2020.588679. eCollection 2020. Front Physiol. 2021. PMID: 33488393 Free PMC article.
Titin Circular RNAs Create a Back-Splice Motif Essential for SRSF10 Splicing.
Tijsen AJ, Cócera Ortega L, Reckman YJ, Zhang X, van der Made I, Aufiero S, Li J, Kamps SC, van den Bout A, Devalla HD, van Spaendonck-Zwarts KY, Engelhardt S, Gepstein L, Ware JS, Pinto YM. Tijsen AJ, et al. Among authors: cocera ortega l. Circulation. 2021 Apr 13;143(15):1502-1512. doi: 10.1161/CIRCULATIONAHA.120.050455. Epub 2021 Feb 15. Circulation. 2021. PMID: 33583186 Free PMC article.
MicroRNAs in extracellular vesicles released from epicardial adipose tissue promote arrhythmogenic conduction slowing.
Ernault AC, de Winter R, Fabrizi B, Bracht JWP, Hau C, van Amersfoorth SCM, Meulendijks ER, Tijsen AJ, Cócera Ortega L, van der Made I, Gasecka A, Driessen AH, Nieuwland R, Boukens BJ, van der Pol E, de Groot JR, Coronel R. Ernault AC, et al. Among authors: cocera ortega l. Heart Rhythm O2. 2023 Nov 2;4(12):805-814. doi: 10.1016/j.hroo.2023.10.007. eCollection 2023 Dec. Heart Rhythm O2. 2023. PMID: 38204457 Free PMC article.
Cardiomyocyte Progenitor Cells as a Functional Gene Delivery Vehicle for Long-Term Biological Pacing.
Végh AMD, den Haan AD, Cócera Ortega L, Verkerk AO, Sluijter JPG, Bakker D, van Amersfoorth S, van Veen TAB, Klerk M, Seppen J, de Bakker JMT, Christoffels VM, Geerts D, Goumans MJTH, Tan HL, Boink GJJ. Végh AMD, et al. Among authors: cocera ortega l. Molecules. 2019 Jan 5;24(1):181. doi: 10.3390/molecules24010181. Molecules. 2019. PMID: 30621310 Free PMC article.
Human Cardiomyocyte Progenitor Cells in Co-culture with Rat Cardiomyocytes Form a Pro-arrhythmic Substrate: Evidence for Two Different Arrhythmogenic Mechanisms.
Smit NW, Cócera Ortega L, Végh AMD, Meijborg VMF, Smits AM, Klerk M, Tijsen AJM, Tan HL, Goumans MHT, Boink GJJ, Coronel R. Smit NW, et al. Among authors: cocera ortega l. Front Physiol. 2017 Oct 12;8:797. doi: 10.3389/fphys.2017.00797. eCollection 2017. Front Physiol. 2017. PMID: 29075204 Free PMC article.