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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1968 1
1988 2
1993 1
1995 2
1996 2
1997 1
1998 2
1999 5
2000 6
2001 5
2002 4
2003 5
2004 6
2005 5
2006 4
2007 5
2008 1
2009 6
2010 8
2011 5
2012 8
2013 8
2014 7
2015 10
2016 6
2017 6
2018 6
2019 5
2020 11
2021 8
2022 3
2023 9
2024 3

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148 results

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Page 1
CDNF rescues motor neurons in models of amyotrophic lateral sclerosis by targeting endoplasmic reticulum stress.
De Lorenzo F, Lüningschrör P, Nam J, Beckett L, Pilotto F, Galli E, Lindholm P, Rüdt von Collenberg C, Mungwa ST, Jablonka S, Kauder J, Thau-Habermann N, Petri S, Lindholm D, Saxena S, Sendtner M, Saarma M, Voutilainen MH. De Lorenzo F, et al. Brain. 2023 Sep 1;146(9):3783-3799. doi: 10.1093/brain/awad087. Brain. 2023. PMID: 36928391 Free PMC article.
A prolyl oligopeptidase inhibitor reduces tau pathology in cellular models and in mice with tauopathy.
Eteläinen TS, Silva MC, Uhari-Väänänen JK, De Lorenzo F, Jäntti MH, Cui H, Chavero-Pieres M, Kilpeläinen T, Mechtler C, Svarcbahs R, Seppälä E, Savinainen JR, Puris E, Fricker G, Gynther M, Julku UH, Huttunen HJ, Haggarty SJ, Myöhänen TT. Eteläinen TS, et al. Sci Transl Med. 2023 Apr 12;15(691):eabq2915. doi: 10.1126/scitranslmed.abq2915. Epub 2023 Apr 12. Sci Transl Med. 2023. PMID: 37043557
Protein phosphatase 2A (PP2A) is a major tau dephosphorylating phosphatase, and a decrease in its activity has been demonstrated in tauopathies, including Alzheimer's disease. Prolyl oligopeptidase is a serine protease that is associated with neurodegeneration, and its inh …
Protein phosphatase 2A (PP2A) is a major tau dephosphorylating phosphatase, and a decrease in its activity has been demonstrated in tauopath …
Encephalitis and poor neuronal death-mediated control of herpes simplex virus in human inherited RIPK3 deficiency.
Liu Z, Garcia Reino EJ, Harschnitz O, Guo H, Chan YH, Khobrekar NV, Hasek ML, Dobbs K, Rinchai D, Materna M, Matuozzo D, Lee D, Bastard P, Chen J, Lee YS, Kim SK, Zhao S, Amin P, Lorenzo L, Seeleuthner Y, Chevalier R, Mazzola L, Gay C, Stephan JL, Milisavljevic B, Boucherit S, Rozenberg F, Perez de Diego R, Dix RD, Marr N, Béziat V, Cobat A, Aubart M, Abel L, Chabrier S, Smith GA, Notarangelo LD, Mocarski ES, Studer L, Casanova JL, Zhang SY. Liu Z, et al. Sci Immunol. 2023 Apr 21;8(82):eade2860. doi: 10.1126/sciimmunol.ade2860. Epub 2023 Apr 21. Sci Immunol. 2023. PMID: 37083451 Free PMC article.
Site-1 protease and lysosomal homeostasis.
Velho RV, De Pace R, Klünder S, Di Lorenzo G, Schweizer M, Braulke T, Pohl S. Velho RV, et al. Biochim Biophys Acta Mol Cell Res. 2017 Nov;1864(11 Pt B):2162-2168. doi: 10.1016/j.bbamcr.2017.06.023. Epub 2017 Jul 8. Biochim Biophys Acta Mol Cell Res. 2017. PMID: 28693924 Free article. Review.
Sphingosine-1-phosphate controls endothelial sphingolipid homeostasis via ORMDL.
Sasset L, Chowdhury KH, Manzo OL, Rubinelli L, Konrad C, Maschek JA, Manfredi G, Holland WL, Di Lorenzo A. Sasset L, et al. EMBO Rep. 2023 Jan 9;24(1):e54689. doi: 10.15252/embr.202254689. Epub 2022 Nov 21. EMBO Rep. 2023. PMID: 36408842 Free PMC article.
Yet, mechanisms governing cellular sensing and regulation of sphingolipid homeostasis remain largely unknown. In yeast, serine palmitoyltransferase, catalyzing the first and rate-limiting step of sphingolipid de novo biosynthesis, is negatively regulated by Orm1 and 2. Low …
Yet, mechanisms governing cellular sensing and regulation of sphingolipid homeostasis remain largely unknown. In yeast, serine palmit …
Sphingolipid Metabolism and Signaling in Endothelial Cell Functions.
Sasset L, Di Lorenzo A. Sasset L, et al. Adv Exp Med Biol. 2022;1372:87-117. doi: 10.1007/978-981-19-0394-6_8. Adv Exp Med Biol. 2022. PMID: 35503177 Review.
In this review we discuss recent insights into the role of ceramide and S1P biosynthesis and signaling in regulating endothelial cell functions, in health and diseases. We also highlight advances into the mechanisms regulating serine palmitoyltransferase, the first and rat …
In this review we discuss recent insights into the role of ceramide and S1P biosynthesis and signaling in regulating endothelial cell functi …
Sphingolipid De Novo Biosynthesis: A Rheostat of Cardiovascular Homeostasis.
Sasset L, Zhang Y, Dunn TM, Di Lorenzo A. Sasset L, et al. Trends Endocrinol Metab. 2016 Nov;27(11):807-819. doi: 10.1016/j.tem.2016.07.005. Epub 2016 Aug 22. Trends Endocrinol Metab. 2016. PMID: 27562337 Free PMC article. Review.
We also highlight advances into the molecular mechanisms regulating serine palmitoyltransferase, the first and rate-limiting enzyme of de novo SL biosynthesis, with an emphasis on the recently discovered inhibitors of serine palmitoyltransferase, ORMDL and NOGO-B pr …
We also highlight advances into the molecular mechanisms regulating serine palmitoyltransferase, the first and rate-limiting enzyme o …
Nogo-A reduces ceramide de novo biosynthesis to protect from heart failure.
Sasset L, Manzo OL, Zhang Y, Marino A, Rubinelli L, Riemma MA, Chalasani MLS, Dasoveanu DC, Roviezzo F, Jankauskas SS, Santulli G, Bucci MR, Lu TT, Di Lorenzo A. Sasset L, et al. Cardiovasc Res. 2023 Mar 31;119(2):506-519. doi: 10.1093/cvr/cvac108. Cardiovasc Res. 2023. PMID: 35815623 Free PMC article.
Recently, we discovered that Nogo-B, a membrane protein of endoplasmic reticulum, abundant in the vascular wall, down-regulates the sphingolipid de novo biosynthesis via serine palmitoyltransferase (SPT), first and rate liming enzyme, to impact vascular functions and blood …
Recently, we discovered that Nogo-B, a membrane protein of endoplasmic reticulum, abundant in the vascular wall, down-regulates the sphingol …
Rewiring Endothelial Sphingolipid Metabolism to Favor S1P Over Ceramide Protects From Coronary Atherosclerosis.
Manzo OL, Nour J, Sasset L, Marino A, Rubinelli L, Palikhe S, Smimmo M, Hu Y, Bucci MR, Borczuk A, Elemento O, Freed JK, Norata GD, Di Lorenzo A. Manzo OL, et al. Circ Res. 2024 Apr 12;134(8):990-1005. doi: 10.1161/CIRCRESAHA.123.323826. Epub 2024 Mar 8. Circ Res. 2024. PMID: 38456287
This finding is a paradigm shift from the current belief that ceramide accrual contributes to endothelial dysfunction. The enzyme SPT (serine palmitoyltransferase) commences de novo biosynthesis of sphingolipids and is inhibited by NOGO-B (reticulon-4B), an ER membrane pro …
This finding is a paradigm shift from the current belief that ceramide accrual contributes to endothelial dysfunction. The enzyme SPT (se …
148 results