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Year Number of Results
1966 1
1976 1
1978 1
1980 1
1983 2
1984 2
1985 1
1986 1
1987 1
1989 2
1990 1
1991 3
1992 2
1993 3
1994 2
1997 4
1998 7
1999 14
2000 8
2001 11
2002 25
2003 27
2004 35
2005 41
2006 34
2007 46
2008 50
2009 53
2010 50
2011 54
2012 76
2013 103
2014 87
2015 98
2016 122
2017 131
2018 136
2019 151
2020 174
2021 255
2022 397
2023 487
2024 202

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2,608 results

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The following term was not found in PubMed: Lioara-Veronica
Page 1
Very-low-density lipoprotein receptor-enhanced lipid metabolism in pancreatic stellate cells promotes pancreatic fibrosis.
Yang X, Chen J, Wang J, Ma S, Feng W, Wu Z, Guo Y, Zhou H, Mi W, Chen W, Yin B, Lin Y. Yang X, et al. Immunity. 2022 Jul 12;55(7):1185-1199.e8. doi: 10.1016/j.immuni.2022.06.001. Epub 2022 Jun 22. Immunity. 2022. PMID: 35738281
Lipoprotein disorder is a common feature of chronic pancreatitis (CP); however, the relationship between lipoprotein disorder and pancreatic fibrotic environment is unclear. Here, we investigated the occurrence and mechanism of pancreatic stellate cell (PSC) …
Lipoprotein disorder is a common feature of chronic pancreatitis (CP); however, the relationship between lipoprotein disorder and pancrea …
Heterocellular OSM-OSMR signalling reprograms fibroblasts to promote pancreatic cancer growth and metastasis.
Lee BY, Hogg EKJ, Below CR, Kononov A, Blanco-Gomez A, Heider F, Xu J, Hutton C, Zhang X, Scheidt T, Beattie K, Lamarca A, McNamara M, Valle JW, Jørgensen C. Lee BY, et al. Nat Commun. 2021 Dec 17;12(1):7336. doi: 10.1038/s41467-021-27607-8. Nat Commun. 2021. PMID: 34921158 Free PMC article.
Pancreatic ductal adenocarcinoma (PDA) is a lethal malignancy with a complex microenvironment. ...Macrophage-secreted OSM stimulates inflammatory gene expression in cancer-associated fibroblasts (CAFs), which in turn induce a pro-tumourigenic environment and engage tumour …
Pancreatic ductal adenocarcinoma (PDA) is a lethal malignancy with a complex microenvironment. ...Macrophage-secreted OSM stimulates …
Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasion.
Murray ER, Menezes S, Henry JC, Williams JL, Alba-Castellón L, Baskaran P, Quétier I, Desai A, Marshall JJT, Rosewell I, Tatari M, Rajeeve V, Khan F, Wang J, Kotantaki P, Tyler EJ, Singh N, Reader CS, Carter EP, Hodivala-Dilke K, Grose RP, Kocher HM, Gavara N, Pearce O, Cutillas P, Marshall JF, Cameron AJM. Murray ER, et al. Cell Rep. 2022 Jan 25;38(4):110227. doi: 10.1016/j.celrep.2021.110227. Cell Rep. 2022. PMID: 35081338 Free PMC article.
In pancreatic ductal adenocarcinoma (PDAC), differentiation of pancreatic stellate cells (PSCs) into myofibroblast-like cancer-associated fibroblasts (CAFs) can both promote and suppress tumor progression. ...PKN2 deletion induces a myofibroblast to in …
In pancreatic ductal adenocarcinoma (PDAC), differentiation of pancreatic stellate cells (PSCs) into myofibrobla …
ESE3/EHF, a promising target of rosiglitazone, suppresses pancreatic cancer stemness by downregulating CXCR4.
Zhou T, Liu J, Xie Y, Yuan S, Guo Y, Bai W, Zhao K, Jiang W, Wang H, Wang H, Zhao T, Huang C, Gao S, Wang X, Yang S, Hao J. Zhou T, et al. Gut. 2022 Feb;71(2):357-371. doi: 10.1136/gutjnl-2020-321952. Epub 2021 Mar 5. Gut. 2022. PMID: 33674341 Free PMC article.
Here, we identified E26 transformation-specific homologous factor (EHF) as a key molecule in decreasing the sensitivity of pancreatic cancer (PC) cells to CSCs' niche stimulus. We also explored a therapeutic strategy to restore the expression of EHF. ...Immunostaini …
Here, we identified E26 transformation-specific homologous factor (EHF) as a key molecule in decreasing the sensitivity of pancreatic …
Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion.
Sousa CM, Biancur DE, Wang X, Halbrook CJ, Sherman MH, Zhang L, Kremer D, Hwang RF, Witkiewicz AK, Ying H, Asara JM, Evans RM, Cantley LC, Lyssiotis CA, Kimmelman AC. Sousa CM, et al. Nature. 2016 Aug 25;536(7617):479-83. doi: 10.1038/nature19084. Epub 2016 Aug 10. Nature. 2016. PMID: 27509858 Free PMC article.
As such, these tumours must alter how they capture and use nutrients to support their metabolic needs. Here we show that stroma-associated pancreatic stellate cells (PSCs) are critical for PDAC metabolism through the secretion of non-essential amino acids (NE …
As such, these tumours must alter how they capture and use nutrients to support their metabolic needs. Here we show that stroma-associated …
Inter- and intra-tumoural heterogeneity in cancer-associated fibroblasts of human pancreatic ductal adenocarcinoma.
Neuzillet C, Tijeras-Raballand A, Ragulan C, Cros J, Patil Y, Martinet M, Erkan M, Kleeff J, Wilson J, Apte M, Tosolini M, Wilson AS, Delvecchio FR, Bousquet C, Paradis V, Hammel P, Sadanandam A, Kocher HM. Neuzillet C, et al. J Pathol. 2019 May;248(1):51-65. doi: 10.1002/path.5224. Epub 2019 Feb 22. J Pathol. 2019. PMID: 30575030 Free PMC article.
Cancer-associated fibroblasts (CAF) are orchestrators of the pancreatic ductal adenocarcinoma (PDAC) microenvironment. Stromal heterogeneity may explain differential pathophysiological roles of the stroma (pro- versus anti-tumoural) in PDAC. ...Each subtype displayed speci …
Cancer-associated fibroblasts (CAF) are orchestrators of the pancreatic ductal adenocarcinoma (PDAC) microenvironment. Stromal hetero …
Pancreatic Tumor Microenvironment.
Wang K, He H. Wang K, et al. Adv Exp Med Biol. 2020;1296:243-257. doi: 10.1007/978-3-030-59038-3_15. Adv Exp Med Biol. 2020. PMID: 34185297
The pancreatic ductal adenocarcinoma (PDAC) microenvironment is a diverse and complex milieu of immune, stromal, and tumor cells and is characterized by a dense stroma, which mediates the interaction between the tumor and the immune system within the tumor microenvi …
The pancreatic ductal adenocarcinoma (PDAC) microenvironment is a diverse and complex milieu of immune, stromal, and tumor cells …
Targeting Pancreatic Stellate Cells in Cancer.
Schnittert J, Bansal R, Prakash J. Schnittert J, et al. Trends Cancer. 2019 Feb;5(2):128-142. doi: 10.1016/j.trecan.2019.01.001. Epub 2019 Feb 1. Trends Cancer. 2019. PMID: 30755305 Review.
Pancreatic stellate cells (PSCs) are the major contributor to the aggressive, metastatic, and resilient nature of pancreatic ductal adenocarcinoma (PDAC), which has a poor prognosis with a 5-year survival rate of 8%. PSCs constitute more than 50% of th …
Pancreatic stellate cells (PSCs) are the major contributor to the aggressive, metastatic, and resilient nature of pa …
Ca2+ signalling underlying pancreatitis.
Gerasimenko JV, Peng S, Tsugorka T, Gerasimenko OV. Gerasimenko JV, et al. Cell Calcium. 2018 Mar;70:95-101. doi: 10.1016/j.ceca.2017.05.010. Epub 2017 May 18. Cell Calcium. 2018. PMID: 28552244 Review.
It is self-resolved in the majority of cases, but could result in chronic pancreatitis (CP) and increased risk of pancreatic cancer (PC). One of the early events in AP is premature activation of digestive pro-enzymes, including trypsinogen, inside pancreatic acinar …
It is self-resolved in the majority of cases, but could result in chronic pancreatitis (CP) and increased risk of pancreatic cancer ( …
Experimental models of pancreatic cancer desmoplasia.
Suklabaidya S, Dash P, Das B, Suresh V, Sasmal PK, Senapati S. Suklabaidya S, et al. Lab Invest. 2018 Jan;98(1):27-40. doi: 10.1038/labinvest.2017.127. Epub 2017 Nov 20. Lab Invest. 2018. PMID: 29155423 Free article. Review.
Desmoplasia is a fibro-inflammatory process and a well-established feature of pancreatic cancer. A key contributor to pancreatic cancer desmoplasia is the pancreatic stellate cell. Various in vitro and in vivo methods have emerged for the isolation, ch …
Desmoplasia is a fibro-inflammatory process and a well-established feature of pancreatic cancer. A key contributor to pancreatic …
2,608 results