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Page 1
Showing results for ligand cai
Search for Ligan Cai instead (1 results)
Ginseng polysaccharides alter the gut microbiota and kynurenine/tryptophan ratio, potentiating the antitumour effect of antiprogrammed cell death 1/programmed cell death ligand 1 (anti-PD-1/PD-L1) immunotherapy.
Huang J, Liu D, Wang Y, Liu L, Li J, Yuan J, Jiang Z, Jiang Z, Hsiao WW, Liu H, Khan I, Xie Y, Wu J, Xie Y, Zhang Y, Fu Y, Liao J, Wang W, Lai H, Shi A, Cai J, Luo L, Li R, Yao X, Fan X, Wu Q, Liu Z, Yan P, Lu J, Yang M, Wang L, Cao Y, Wei H, Leung EL. Huang J, et al. Gut. 2022 Apr;71(4):734-745. doi: 10.1136/gutjnl-2020-321031. Epub 2021 May 18. Gut. 2022. PMID: 34006584 Free PMC article.
OBJECTIVE: Programmed death 1 and its ligand 1 (PD-1/PD-L1) immunotherapy is promising for late-stage lung cancer treatment, however, the response rate needs to be improved. ...
OBJECTIVE: Programmed death 1 and its ligand 1 (PD-1/PD-L1) immunotherapy is promising for late-stage lung cancer treatment, however, …
C-C motif chemokine ligand 5 confines liver regeneration by down-regulating reparative macrophage-derived hepatocyte growth factor in a forkhead box O 3a-dependent manner.
Huang M, Jiao J, Cai H, Zhang Y, Xia Y, Lin J, Shang Z, Qian Y, Wang F, Wu H, Kong X, Gu J. Huang M, et al. Hepatology. 2022 Dec;76(6):1706-1722. doi: 10.1002/hep.32458. Epub 2022 May 5. Hepatology. 2022. PMID: 35288960 Free PMC article.
Although inflammation plays an important role in controlling LR, the underlying mechanisms still remain obscure. APPROACH AND RESULTS: We identified C-C motif chemokine ligand (CCL) 5 as an important negative regulator for LR. CCL5 levels were elevated after partial hepate …
Although inflammation plays an important role in controlling LR, the underlying mechanisms still remain obscure. APPROACH AND RESULTS: We id …
Meteorin-like promotes heart repair through endothelial KIT receptor tyrosine kinase.
Reboll MR, Klede S, Taft MH, Cai CL, Field LJ, Lavine KJ, Koenig AL, Fleischauer J, Meyer J, Schambach A, Niessen HW, Kosanke M, van den Heuvel J, Pich A, Bauersachs J, Wu X, Zheng L, Wang Y, Korf-Klingebiel M, Polten F, Wollert KC. Reboll MR, et al. Science. 2022 Jun 17;376(6599):1343-1347. doi: 10.1126/science.abn3027. Epub 2022 Jun 16. Science. 2022. PMID: 35709278 Free PMC article.
We identify the monocyte- and macrophage-derived cytokine METRNL (meteorin-like) as a driver of postinfarction angiogenesis and high-affinity ligand for the stem cell factor receptor KIT (KIT receptor tyrosine kinase). ...Metrnl-deficient mice failed to mount this KIT-depe …
We identify the monocyte- and macrophage-derived cytokine METRNL (meteorin-like) as a driver of postinfarction angiogenesis and high-affinit …
Aptamer-Based Targeted Drug Delivery Systems: Current Potential and Challenges.
He F, Wen N, Xiao D, Yan J, Xiong H, Cai S, Liu Z, Liu Y. He F, et al. Curr Med Chem. 2020;27(13):2189-2219. doi: 10.2174/0929867325666181008142831. Curr Med Chem. 2020. PMID: 30295183 Review.
Aptamers can bind to the receptors on the cell membrane and mediate themselves or conjugated nanoparticles to enter into cells. Therefore, aptamers can be served as ideal targeting ligands for drug delivery. Since their excellent properties, different aptamer-mediated drug …
Aptamers can bind to the receptors on the cell membrane and mediate themselves or conjugated nanoparticles to enter into cells. Therefore, a …
GPCR activation and GRK2 assembly by a biased intracellular agonist.
Duan J, Liu H, Zhao F, Yuan Q, Ji Y, Cai X, He X, Li X, Li J, Wu K, Gao T, Zhu S, Lin S, Wang MW, Cheng X, Yin W, Jiang Y, Yang D, Xu HE. Duan J, et al. Nature. 2023 Aug;620(7974):676-681. doi: 10.1038/s41586-023-06395-9. Epub 2023 Aug 2. Nature. 2023. PMID: 37532940
Phosphorylation of G-protein-coupled receptors (GPCRs) by GPCR kinases (GRKs) desensitizes G-protein signalling and promotes arrestin signalling, which is also modulated by biased ligands(1-6). The molecular assembly of GRKs on GPCRs and the basis of GRK-mediated biased si …
Phosphorylation of G-protein-coupled receptors (GPCRs) by GPCR kinases (GRKs) desensitizes G-protein signalling and promotes arrestin signal …
Transcriptome-scale super-resolved imaging in tissues by RNA seqFISH.
Eng CL, Lawson M, Zhu Q, Dries R, Koulena N, Takei Y, Yun J, Cronin C, Karp C, Yuan GC, Cai L. Eng CL, et al. Nature. 2019 Apr;568(7751):235-239. doi: 10.1038/s41586-019-1049-y. Epub 2019 Mar 25. Nature. 2019. PMID: 30911168 Free PMC article.
In addition, seqFISH+ reveals subcellular mRNA localization patterns in cells and ligand-receptor pairs across neighbouring cells. This technology demonstrates the ability to generate spatial cell atlases and to perform discovery-driven studies of biological processes in s …
In addition, seqFISH+ reveals subcellular mRNA localization patterns in cells and ligand-receptor pairs across neighbouring cells. Th …
Tail engagement of arrestin at the glucagon receptor.
Chen K, Zhang C, Lin S, Yan X, Cai H, Yi C, Ma L, Chu X, Liu Y, Zhu Y, Han S, Zhao Q, Wu B. Chen K, et al. Nature. 2023 Aug;620(7975):904-910. doi: 10.1038/s41586-023-06420-x. Epub 2023 Aug 9. Nature. 2023. PMID: 37558880 Free PMC article.
Here we report two structures of the glucagon receptor (GCGR) bound to beta-arrestin 1 (betaarr1) in glucagon-bound and ligand-free states. These structures reveal a receptor tail-engaged binding mode of betaarr1 with many unique features, to our knowledge, not previously …
Here we report two structures of the glucagon receptor (GCGR) bound to beta-arrestin 1 (betaarr1) in glucagon-bound and ligand-free s …
Common activation mechanism of class A GPCRs.
Zhou Q, Yang D, Wu M, Guo Y, Guo W, Zhong L, Cai X, Dai A, Jang W, Shakhnovich EI, Liu ZJ, Stevens RC, Lambert NA, Babu MM, Wang MW, Zhao S. Zhou Q, et al. Elife. 2019 Dec 19;8:e50279. doi: 10.7554/eLife.50279. Elife. 2019. PMID: 31855179 Free PMC article.
The pathway unifies previous findings into a common activation mechanism and strings together the scattered key motifs such as CWxP, DRY, Na(+) pocket, NPxxY and PIF, thereby directly linking the bottom of ligand-binding pocket with G-protein coupling region. Site-directed …
The pathway unifies previous findings into a common activation mechanism and strings together the scattered key motifs such as CWxP, DRY, Na …
Ligand recognition mechanism of the human relaxin family peptide receptor 4 (RXFP4).
Chen Y, Zhou Q, Wang J, Xu Y, Wang Y, Yan J, Wang Y, Zhu Q, Zhao F, Li C, Chen CW, Cai X, Bathgate RAD, Shen C, Eric Xu H, Yang D, Liu H, Wang MW. Chen Y, et al. Nat Commun. 2023 Jan 30;14(1):492. doi: 10.1038/s41467-023-36182-z. Nat Commun. 2023. PMID: 36717591 Free PMC article.
Here, we report three cryo-electron microscopy structures of RXFP4-G(i) protein complexes in the presence of the endogenous ligand insulin-like peptide 5 (INSL5) or one of the two small molecule agonists, compound 4 and DC591053. ...Together with mutagenesis and functional …
Here, we report three cryo-electron microscopy structures of RXFP4-G(i) protein complexes in the presence of the endogenous ligand in …
CAR NK-92 cells targeting DLL3 kill effectively small cell lung cancer cells in vitro and in vivo.
Liu M, Huang W, Guo Y, Zhou Y, Zhi C, Chen J, Li J, He J, Lian H, Zhou J, Ye X, Hu Y, Hu H, Liu Z, Huang J, Lin L, Cai M, Wang X, Huang J, Zhang Z, Zhu K, Zhao Q, Cao B. Liu M, et al. J Leukoc Biol. 2022 Oct;112(4):901-911. doi: 10.1002/JLB.5MA0122-467R. Epub 2022 Jan 28. J Leukoc Biol. 2022. PMID: 35088475
However, their potential applications have not been explored in SCLC. Delta-like ligand 3 (DLL3) has been reported to be overexpressed in SCLC and may be a rational target for CAR NK immunotherapy. ...
However, their potential applications have not been explored in SCLC. Delta-like ligand 3 (DLL3) has been reported to be overexpresse …
2,531 results