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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1908 1
1920 1
1925 2
1928 2
1929 1
1930 1
1931 2
1932 2
1933 3
1934 1
1940 1
1944 1
1948 1
1949 1
1951 2
1956 2
1959 2
1961 3
1962 5
1963 2
1964 3
1965 2
1966 3
1967 5
1968 9
1969 9
1970 16
1971 22
1972 28
1973 36
1974 39
1975 180
1976 221
1977 159
1978 179
1979 214
1980 219
1981 280
1982 304
1983 423
1984 494
1985 564
1986 610
1987 648
1988 618
1989 802
1990 819
1991 859
1992 909
1993 950
1994 1063
1995 1123
1996 1216
1997 1180
1998 1270
1999 1350
2000 1481
2001 1521
2002 1506
2003 1926
2004 2349
2005 2629
2006 2789
2007 3077
2008 3187
2009 3350
2010 3687
2011 4208
2012 4538
2013 4799
2014 5151
2015 5396
2016 5592
2017 5606
2018 5808
2019 6193
2020 6602
2021 6563
2022 5944
2023 5396
2024 2648

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106,816 results

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Page 1
Showing results for line lower
Search for Lien Loier instead (1 results)
Gout.
Dalbeth N, Choi HK, Joosten LAB, Khanna PP, Matsuo H, Perez-Ruiz F, Stamp LK. Dalbeth N, et al. Nat Rev Dis Primers. 2019 Sep 26;5(1):69. doi: 10.1038/s41572-019-0115-y. Nat Rev Dis Primers. 2019. PMID: 31558729 Review.
Gout typically presents as an acute, self-limiting inflammatory monoarthritis that affects the joints of the lower limb. Elevated serum urate level (hyperuricaemia) is the major risk factor for MSU crystal deposition and development of gout. ...Allopurinol is the first- …
Gout typically presents as an acute, self-limiting inflammatory monoarthritis that affects the joints of the lower limb. Elevated ser …
Metformin: historical overview.
Bailey CJ. Bailey CJ. Diabetologia. 2017 Sep;60(9):1566-1576. doi: 10.1007/s00125-017-4318-z. Epub 2017 Aug 3. Diabetologia. 2017. PMID: 28776081
Metformin (dimethylbiguanide) has become the preferred first-line oral blood glucose-lowering agent to manage type 2 diabetes. ...Sixty years after its introduction in diabetes treatment, metformin has become the most prescribed glucose-lowering medicine worl …
Metformin (dimethylbiguanide) has become the preferred first-line oral blood glucose-lowering agent to manage type 2 diabetes. …
Cholesterol Lowering Drugs.
Feingold KR. Feingold KR. 2024 Feb 12. In: Feingold KR, Anawalt B, Blackman MR, Boyce A, Chrousos G, Corpas E, de Herder WW, Dhatariya K, Dungan K, Hofland J, Kalra S, Kaltsas G, Kapoor N, Koch C, Kopp P, Korbonits M, Kovacs CS, Kuohung W, Laferrère B, Levy M, McGee EA, McLachlan R, New M, Purnell J, Sahay R, Shah AS, Singer F, Sperling MA, Stratakis CA, Trence DL, Wilson DP, editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000–. 2024 Feb 12. In: Feingold KR, Anawalt B, Blackman MR, Boyce A, Chrousos G, Corpas E, de Herder WW, Dhatariya K, Dungan K, Hofland J, Kalra S, Kaltsas G, Kapoor N, Koch C, Kopp P, Korbonits M, Kovacs CS, Kuohung W, Laferrère B, Levy M, McGee EA, McLachlan R, New M, Purnell J, Sahay R, Shah AS, Singer F, Sperling MA, Stratakis CA, Trence DL, Wilson DP, editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000–. PMID: 27809434 Free Books & Documents. Review.
There are currently several different classes of drugs available for lowering cholesterol levels. There are currently seven HMG-CoA reductase inhibitors (statins) approved for lowering cholesterol levels and they are the first line drugs for treating choleste …
There are currently several different classes of drugs available for lowering cholesterol levels. There are currently seven HMG-CoA r …
Evaluating gliclazide for the treatment of type 2 diabetes mellitus.
Tomlinson B, Li YH, Chan P. Tomlinson B, et al. Expert Opin Pharmacother. 2022 Dec;23(17):1869-1877. doi: 10.1080/14656566.2022.2141108. Epub 2022 Nov 10. Expert Opin Pharmacother. 2022. PMID: 36300277 Review.
INTRODUCTION: Sulfonylureas have been the standard second-line treatment after failure of metformin monotherapy in patients with type 2 diabetes (T2D) but they are becoming less popular as the newer glucose-lowering agents have a relatively lower risk of hypo …
INTRODUCTION: Sulfonylureas have been the standard second-line treatment after failure of metformin monotherapy in patients with type …
Thiazide and the Thiazide-Like Diuretics: Review of Hydrochlorothiazide, Chlorthalidone, and Indapamide.
Ernst ME, Fravel MA. Ernst ME, et al. Am J Hypertens. 2022 Jul 1;35(7):573-586. doi: 10.1093/ajh/hpac048. Am J Hypertens. 2022. PMID: 35404993 Review.
They are reliably effective as monotherapy in a majority of hypertensive patients, and augment the efficacy of other classes of antihypertensives when used in combination. Importantly, a thiazide-based treatment regimen lowers cardiovascular events, and their sturdy effect …
They are reliably effective as monotherapy in a majority of hypertensive patients, and augment the efficacy of other classes of antihyperten …
15LO1 dictates glutathione redox changes in asthmatic airway epithelium to worsen type 2 inflammation.
Nagasaki T, Schuyler AJ, Zhao J, Samovich SN, Yamada K, Deng Y, Ginebaugh SP, Christenson SA, Woodruff PG, Fahy JV, Trudeau JB, Stoyanovsky D, Ray A, Tyurina YY, Kagan VE, Wenzel SE. Nagasaki T, et al. J Clin Invest. 2022 Jan 4;132(1):e151685. doi: 10.1172/JCI151685. J Clin Invest. 2022. PMID: 34762602 Free PMC article.
GSH, GSSG (enzymatic assays), 15LO1, GPX4, SLC7A11, and T2 biomarkers (Western blot and RNA-Seq) were measured in asthmatic and healthy control (HC) cells and fluids, with siRNA knockdown as appropriate. GSSG was higher and GSH:GSSG lower in asthmatic compared with HC BAL …
GSH, GSSG (enzymatic assays), 15LO1, GPX4, SLC7A11, and T2 biomarkers (Western blot and RNA-Seq) were measured in asthmatic and healthy cont …
Remnant lipoproteins.
Varbo A, Nordestgaard BG. Varbo A, et al. Curr Opin Lipidol. 2017 Aug;28(4):300-307. doi: 10.1097/MOL.0000000000000429. Curr Opin Lipidol. 2017. PMID: 28548974 Review.
Many smaller scale studies and post hoc analyses show that remnant cholesterol can be lowered by different types of drugs; however, results from large scale studies with the primary aim of reducing cardiovascular disease risk through lowering of remnant cholesterol …
Many smaller scale studies and post hoc analyses show that remnant cholesterol can be lowered by different types of drugs; however, r …
Lower risk of dementia with pioglitazone, compared with other second-line treatments, in metformin-based dual therapy: a population-based longitudinal study.
Lu CH, Yang CY, Li CY, Hsieh CY, Ou HT. Lu CH, et al. Diabetologia. 2018 Mar;61(3):562-573. doi: 10.1007/s00125-017-4499-5. Epub 2017 Nov 14. Diabetologia. 2018. PMID: 29138876
Primary analyses included 51,415 individuals aged 65 years without dementia events in the first year of second-line glucose-lowering treatment. Study subjects were classified into mutually exclusive groups according to various second-line glucose-lowering …
Primary analyses included 51,415 individuals aged 65 years without dementia events in the first year of second-line glucose-loweri …
[Statin intolerance-Statin tolerance].
Vogt A. Vogt A. Inn Med (Heidelb). 2023 Jul;64(7):622-628. doi: 10.1007/s00108-023-01535-9. Epub 2023 Jun 15. Inn Med (Heidelb). 2023. PMID: 37318556 Review. German.
BACKGROUND: Statins are the first-line treatment for reducing low-density lipoprotein (LDL) cholesterol levels, because the evidence regarding safety, tolerability, and reduction of cardiovascular morbidity and mortality is very good. ...Nevertheless, LDL cholesterol value …
BACKGROUND: Statins are the first-line treatment for reducing low-density lipoprotein (LDL) cholesterol levels, because the evidence …
What is really new in triglyceride guidelines?
Hussain A, Al Rifai M, Hermel M, Slipczuk L, Virani SS. Hussain A, et al. Curr Opin Endocrinol Diabetes Obes. 2023 Apr 1;30(2):73-80. doi: 10.1097/MED.0000000000000802. Epub 2023 Feb 1. Curr Opin Endocrinol Diabetes Obes. 2023. PMID: 36722448 Review.
SUMMARY: Current guidelines and expert consensus documents from multiple societies strongly endorse therapeutic lifestyle interventions to effectively lower TG as the first-line therapy for treatment of hypertriglyceridemia. Evaluation and treatment of secondary cau …
SUMMARY: Current guidelines and expert consensus documents from multiple societies strongly endorse therapeutic lifestyle interventions to e …
106,816 results
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