Tin (IV) chloride-promoted one-pot synthesis of novel tacrine analogues

Molecules. 2011 Feb 22;16(2):1878-87. doi: 10.3390/molecules16021878.

Abstract

A facile synthesis of potential acetylcholinesterase (AChE) inhibitors, the tacrine analogues 3a-p, has been accomplished by direct cyclocondensation of 1-aryl-4-cyano-5-aminopyrazole with β-ketoesters using tin(IV) chloride as catalyst. The structures of all the compounds have been confirmed by IR, ¹H- and ¹³C-NMR.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Esters / chemistry
  • Humans
  • Molecular Structure
  • Nitriles / chemistry
  • Nuclear Magnetic Resonance, Biomolecular
  • Pyrazoles / chemistry
  • Tacrine / analogs & derivatives*
  • Tacrine / chemical synthesis*
  • Tacrine / chemistry
  • Tin Compounds / chemistry*

Substances

  • Esters
  • Nitriles
  • Pyrazoles
  • Tin Compounds
  • stannous chloride
  • Tacrine