Abstract
A facile synthesis of potential acetylcholinesterase (AChE) inhibitors, the tacrine analogues 3a-p, has been accomplished by direct cyclocondensation of 1-aryl-4-cyano-5-aminopyrazole with β-ketoesters using tin(IV) chloride as catalyst. The structures of all the compounds have been confirmed by IR, ¹H- and ¹³C-NMR.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Esters / chemistry
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Humans
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Molecular Structure
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Nitriles / chemistry
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Nuclear Magnetic Resonance, Biomolecular
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Pyrazoles / chemistry
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Tacrine / analogs & derivatives*
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Tacrine / chemical synthesis*
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Tacrine / chemistry
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Tin Compounds / chemistry*
Substances
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Esters
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Nitriles
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Pyrazoles
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Tin Compounds
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stannous chloride
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Tacrine