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Peritumoral activation of the Hippo pathway effectors YAP and TAZ suppresses liver cancer in mice.
Moya IM, Castaldo SA, Van den Mooter L, Soheily S, Sansores-Garcia L, Jacobs J, Mannaerts I, Xie J, Verboven E, Hillen H, Algueró-Nadal A, Karaman R, Van Haele M, Kowalczyk W, De Waegeneer M, Verhulst S, Karras P, van Huffel L, Zender L, Marine JC, Roskams T, Johnson R, Aerts S, van Grunsven LA, Halder G. Moya IM, et al. Among authors: van huffel l. Science. 2019 Nov 22;366(6468):1029-1034. doi: 10.1126/science.aaw9886. Science. 2019. PMID: 31754005
A Novel Irreversible TEAD Inhibitor, SWTX-143, Blocks Hippo Pathway Transcriptional Output and Causes Tumor Regression in Preclinical Mesothelioma Models.
Hillen H, Candi A, Vanderhoydonck B, Kowalczyk W, Sansores-Garcia L, Kesikiadou EC, Van Huffel L, Spiessens L, Nijs M, Soons E, Haeck W, Klaassen H, Smets W, Spieser SA, Marchand A, Chaltin P, Ciesielski F, Debaene F, Chen L, Kamal A, Gwaltney SL, Versele M, Halder GA. Hillen H, et al. Among authors: van huffel l. Mol Cancer Ther. 2024 Jan 3;23(1):3-13. doi: 10.1158/1535-7163.MCT-22-0681. Mol Cancer Ther. 2024. PMID: 37748190
Glial β-oxidation regulates Drosophila energy metabolism.
Schulz JG, Laranjeira A, Van Huffel L, Gärtner A, Vilain S, Bastianen J, Van Veldhoven PP, Dotti CG. Schulz JG, et al. Among authors: van huffel l. Sci Rep. 2015 Jan 15;5:7805. doi: 10.1038/srep07805. Sci Rep. 2015. PMID: 25588812 Free PMC article.
Modulation of the Hippo pathway and organ growth by RNA processing proteins.
Mach J, Atkins M, Gajewski KM, Mottier-Pavie V, Sansores-Garcia L, Xie J, Mills RA, Kowalczyk W, Van Huffel L, Mills GB, Halder G. Mach J, et al. Among authors: van huffel l. Proc Natl Acad Sci U S A. 2018 Oct 16;115(42):10684-10689. doi: 10.1073/pnas.1807325115. Epub 2018 Sep 26. Proc Natl Acad Sci U S A. 2018. PMID: 30257938 Free PMC article.
Regeneration Defects in Yap and Taz Mutant Mouse Livers Are Caused by Bile Duct Disruption and Cholestasis.
Verboven E, Moya IM, Sansores-Garcia L, Xie J, Hillen H, Kowalczyk W, Vella G, Verhulst S, Castaldo SA, Algueró-Nadal A, Romanelli L, Mercader-Celma C, Souza NA, Soheily S, Van Huffel L, Van Brussel T, Lambrechts D, Roskams T, Lemaigre FP, Bergers G, van Grunsven LA, Halder G. Verboven E, et al. Among authors: van huffel l. Gastroenterology. 2021 Feb;160(3):847-862. doi: 10.1053/j.gastro.2020.10.035. Epub 2020 Oct 28. Gastroenterology. 2021. PMID: 33127392 Free article.