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Year Number of Results
2003 1
2005 2
2006 2
2007 2
2008 5
2009 4
2010 2
2011 2
2012 2
2013 5
2014 5
2015 1
2016 1
2017 4
2018 6
2019 3
2020 7
2021 7
2022 4
2023 7
2024 3

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Page 1
Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C.
Weiss A, Lorthiois E, Barys L, Beyer KS, Bomio-Confaglia C, Burks H, Chen X, Cui X, de Kanter R, Dharmarajan L, Fedele C, Gerspacher M, Guthy DA, Head V, Jaeger A, Núñez EJ, Kearns JD, Leblanc C, Maira SM, Murphy J, Oakman H, Ostermann N, Ottl J, Rigollier P, Roman D, Schnell C, Sedrani R, Shimizu T, Stringer R, Vaupel A, Voshol H, Wessels P, Widmer T, Wilcken R, Xu K, Zecri F, Farago AF, Cotesta S, Brachmann SM. Weiss A, et al. Among authors: leblanc c. Cancer Discov. 2022 Jun 2;12(6):1500-1517. doi: 10.1158/2159-8290.CD-22-0158. Cancer Discov. 2022. PMID: 35404998 Free PMC article.
Isoprostanoid Profiling of Marine Microalgae.
Vigor C, Oger C, Reversat G, Rocher A, Zhou B, Linares-Maurizi A, Guy A, Bultel-Poncé V, Galano JM, Vercauteren J, Durand T, Potin P, Tonon T, Leblanc C. Vigor C, et al. Among authors: leblanc c. Biomolecules. 2020 Jul 18;10(7):1073. doi: 10.3390/biom10071073. Biomolecules. 2020. PMID: 32708411 Free PMC article.
Chemical Optimization of CBL0137 for Human African Trypanosomiasis Lead Drug Discovery.
Singh B, Sharma A, Gunaganti N, Rivers M, Gadekar PK, Greene B, Chichioco M, Sanz-Rodriguez CE, Fu C, LeBlanc C, Burchfield E, Sharif N, Hoffman B, Kumar G, Purmal A, Mensa-Wilmot K, Pollastri MP. Singh B, et al. Among authors: leblanc c. J Med Chem. 2023 Feb 9;66(3):1972-1989. doi: 10.1021/acs.jmedchem.2c01767. Epub 2023 Jan 25. J Med Chem. 2023. PMID: 36695630 Free PMC article.
Identification of novel anti-amoebic pharmacophores from kinase inhibitor chemotypes.
Ferrins L, Buskes MJ, Kapteyn MM, Engels HN, Enos SE, Lu C, Klug DM, Singh B, Quotadamo A, Bachovchin K, Tear WF, Spaulding AE, Forbes KC, Bag S, Rivers M, LeBlanc C, Burchfield E, Armand JR, Diaz-Gonzalez R, Ceballos-Perez G, García-Hernández R, Pérez-Moreno G, Bosch-Navarrete C, Ruiz-Pérez LM, Gamarro F, González-Pacanowska D, Navarro M, Mensa-Wilmot K, Pollastri MP, Kyle DE, Rice CA. Ferrins L, et al. Among authors: leblanc c. Front Microbiol. 2023 May 10;14:1149145. doi: 10.3389/fmicb.2023.1149145. eCollection 2023. Front Microbiol. 2023. PMID: 37234530 Free PMC article.
JDQ443, a Structurally Novel, Pyrazole-Based, Covalent Inhibitor of KRASG12C for the Treatment of Solid Tumors.
Lorthiois E, Gerspacher M, Beyer KS, Vaupel A, Leblanc C, Stringer R, Weiss A, Wilcken R, Guthy DA, Lingel A, Bomio-Confaglia C, Machauer R, Rigollier P, Ottl J, Arz D, Bernet P, Desjonqueres G, Dussauge S, Kazic-Legueux M, Lozac'h MA, Mura C, Sorge M, Todorov M, Warin N, Zink F, Voshol H, Zecri FJ, Sedrani RC, Ostermann N, Brachmann SM, Cotesta S. Lorthiois E, et al. Among authors: leblanc c. J Med Chem. 2022 Dec 22;65(24):16173-16203. doi: 10.1021/acs.jmedchem.2c01438. Epub 2022 Nov 18. J Med Chem. 2022. PMID: 36399068
Corrigendum: Identification of novel anti-amoebic pharmacophores from kinase inhibitor chemotypes.
Ferrins L, Buskes MJ, Kapteyn MM, Engels HN, Enos SE, Lu C, Klug DM, Singh B, Quotadamo A, Bachovchin K, Tear WF, Spaulding AE, Forbes KC, Bag S, Rivers M, LeBlanc C, Burchfield E, Armand JR, Diaz-Gonzalez R, Ceballos-Perez G, García-Hernández R, Pérez-Moreno G, Bosch-Navarrete C, Gómez-Liñán C, Ruiz-Pérez LM, Gamarro F, González-Pacanowska D, Navarro M, Mensa-Wilmot K, Pollastri MP, Kyle DE, Rice CA. Ferrins L, et al. Among authors: leblanc c. Front Microbiol. 2023 Oct 25;14:1304196. doi: 10.3389/fmicb.2023.1304196. eCollection 2023. Front Microbiol. 2023. PMID: 37954236 Free PMC article.
70 results