Treatment of congenital thrombocytopenia and decreased collagen reactivity in G6b-B-deficient mice.
Mazharian A, Maître B, Bornert A, Hennequin D, Lourenco-Rodrigues M, Geer MJ, Smith CW, Heising S, Walter M, Montel F, Walker LSK, de la Salle H, Watson SP, Gachet C, Senis YA.
Mazharian A, et al.
Blood Adv. 2023 Jan 10;7(1):46-59. doi: 10.1182/bloodadvances.2022008873.
Blood Adv. 2023.
PMID: 36269841
Free PMC article.
Platelets are almost completely devoid of the glycoprotein VI (GPVI)-FcRgamma-chain collagen receptor complex, have reduced collagen integrin alpha2beta1, elevated Syk tyrosine kinase activity, and a subset has increased surface immunoglobulins. A similar phenotype was recently r …
Platelets are almost completely devoid of the glycoprotein VI (GPVI)-FcRgamma-chain collagen receptor complex, have reduced collagen integri …