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A new naphthalene derivative with anti-amyloidogenic activity as potential therapeutic agent for Alzheimer's disease.
Rivera-Marrero S, Bencomo-Martínez A, Orta Salazar E, Sablón-Carrazana M, García-Pupo L, Zoppolo F, Arredondo F, Dapueto R, Daniela Santi M, Kreimerman I, Pardo T, Reyes L, Galán L, León-Chaviano S, Espinosa-Rodríguez LA, Menéndez-Soto Del Valle R, Savio E, Díaz Cintra S, Rodríguez-Tanty C. Rivera-Marrero S, et al. Among authors: garcia pupo l. Bioorg Med Chem. 2020 Oct 15;28(20):115700. doi: 10.1016/j.bmc.2020.115700. Epub 2020 Aug 11. Bioorg Med Chem. 2020. PMID: 33069076
Novel arylidene malonate derivative, KM-34, showed neuroprotective effects on in vitro and in vivo models of ischemia/reperfusion.
Ramírez-Sánchez J, Wong-Guerra M, Fonseca-Fonseca LA, Simões-Pires EN, García-Pupo L, Ochoa-Rodríguez E, Verdecia-Reyes Y, Delgado-Hernández R, Salbego C, Souza DO, Pardo-Andreu GL, Nuñez-Figueredo Y. Ramírez-Sánchez J, et al. Among authors: garcia pupo l. Eur J Pharmacol. 2021 May 15;899:174025. doi: 10.1016/j.ejphar.2021.174025. Epub 2021 Mar 17. Eur J Pharmacol. 2021. PMID: 33722590 Free article.
Amylovis-201 enhances physiological memory formation and rescues memory and hippocampal cell loss in a streptozotocin-induced Alzheimer's disease animal model.
Mercerón-Martínez D, Alacán Ricardo L, Bejerano Pina A, Orama Rojo N, Expósito Seco A, Vega Hurtado Y, Estupiñán Días B, Fernández I, García Pupo L, Sablón Carrazana M, Rodríguez-Tanty C, Menéndez Soto Del Valle R, Almaguer-Melian W. Mercerón-Martínez D, et al. Among authors: garcia pupo l. Brain Res. 2024 May 15;1831:148848. doi: 10.1016/j.brainres.2024.148848. Epub 2024 Mar 2. Brain Res. 2024. PMID: 38432261
Semi-synthetic sapogenin exerts neuroprotective effects by skewing the brain ischemia reperfusion transcriptome towards inflammatory resolution.
García-Pupo L, Sánchez JR, Ratman D, Pérez-Novo C, Declerck K, De Bosscher K, Markakis MN, Beemster G, Zaldo A, Nuñez Figueredo Y, Delgado-Hernández R, Vanden Berghe W. García-Pupo L, et al. Brain Behav Immun. 2017 Aug;64:103-115. doi: 10.1016/j.bbi.2017.04.002. Epub 2017 Apr 6. Brain Behav Immun. 2017. PMID: 28390980