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Page 1
Clp-targeting BacPROTACs impair mycobacterial proteostasis and survival.
Hoi DM, Junker S, Junk L, Schwechel K, Fischel K, Podlesainski D, Hawkins PME, van Geelen L, Kaschani F, Leodolter J, Morreale FE, Kleine S, Guha S, Rumpel K, Schmiedel VM, Weinstabl H, Meinhart A, Payne RJ, Kaiser M, Hartl M, Boehmelt G, Kazmaier U, Kalscheuer R, Clausen T. Hoi DM, et al. Among authors: van geelen l. Cell. 2023 May 11;186(10):2176-2192.e22. doi: 10.1016/j.cell.2023.04.009. Epub 2023 May 2. Cell. 2023. PMID: 37137307 Free article.
(Some) current concepts in antibacterial drug discovery.
van Geelen L, Meier D, Rehberg N, Kalscheuer R. van Geelen L, et al. Appl Microbiol Biotechnol. 2018 Apr;102(7):2949-2963. doi: 10.1007/s00253-018-8843-6. Epub 2018 Feb 17. Appl Microbiol Biotechnol. 2018. PMID: 29455386 Review.
Colletodiol derivatives of the endophytic fungus Trichocladium sp.
Simons VE, Mándi A, Frank M, van Geelen L, Tran-Cong N, Albrecht D, Coort A, Gebhard C, Kurtán T, Kalscheuer R. Simons VE, et al. Among authors: van geelen l. Fitoterapia. 2024 Mar 19;175:105914. doi: 10.1016/j.fitote.2024.105914. Online ahead of print. Fitoterapia. 2024. PMID: 38508500 Free article.
3-O-Methyl-Alkylgallates Inhibit Fatty Acid Desaturation in Mycobacterium tuberculosis.
Rehberg N, Omeje E, Ebada SS, van Geelen L, Liu Z, Sureechatchayan P, Kassack MU, Ioerger TR, Proksch P, Kalscheuer R. Rehberg N, et al. Among authors: van geelen l. Antimicrob Agents Chemother. 2019 Aug 23;63(9):e00136-19. doi: 10.1128/AAC.00136-19. Print 2019 Sep. Antimicrob Agents Chemother. 2019. PMID: 31209015 Free PMC article.
Homo-BacPROTAC-induced degradation of ClpC1 as a strategy against drug-resistant mycobacteria.
Junk L, Schmiedel VM, Guha S, Fischel K, Greb P, Vill K, Krisilia V, van Geelen L, Rumpel K, Kaur P, Krishnamurthy RV, Narayanan S, Shandil RK, Singh M, Kofink C, Mantoulidis A, Biber P, Gmaschitz G, Kazmaier U, Meinhart A, Leodolter J, Hoi D, Junker S, Morreale FE, Clausen T, Kalscheuer R, Weinstabl H, Boehmelt G. Junk L, et al. Among authors: van geelen l. Nat Commun. 2024 Mar 5;15(1):2005. doi: 10.1038/s41467-024-46218-7. Nat Commun. 2024. PMID: 38443338 Free PMC article.
Novel reverse thia-analogs of fosmidomycin: Synthesis and antiplasmodial activity.
Lienau C, Gräwert T, Alves Avelar LA, Illarionov B, Held J, Knaab TC, Lungerich B, van Geelen L, Meier D, Geissler S, Cynis H, Riederer U, Buchholz M, Kalscheuer R, Bacher A, Mordmüller B, Fischer M, Kurz T. Lienau C, et al. Among authors: van geelen l. Eur J Med Chem. 2019 Nov 1;181:111555. doi: 10.1016/j.ejmech.2019.07.058. Epub 2019 Jul 22. Eur J Med Chem. 2019. PMID: 31382119
16 results