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Enhanced Antigiardial Effect of Omeprazole Analog Benzimidazole Compounds.
Hernández-Ochoa B, Gómez-Manzo S, Sánchez-Carrillo A, Marcial-Quino J, Rocha-Ramírez LM, Santos-Segura A, Ramírez-Nava EJ, Arreguin-Espinosa R, Cuevas-Cruz M, Méndez-Tenorio A, Calderón-Jaimes E. Hernández-Ochoa B, et al. Molecules. 2020 Sep 1;25(17):3979. doi: 10.3390/molecules25173979. Molecules. 2020. PMID: 32882836 Free PMC article.
Among the target compounds, H-BZM2, O(2)N-BZM7, and O(2)N-BZM9 had greater antigiardial activity (IC(50): 36, 14, and 17 M on trophozoites), and inhibited the TPI enzyme (K(2): 2.3, 3.2, and 2.8 M(-1) s(-1)) respectively, loading alterations on the secondary structu …
Among the target compounds, H-BZM2, O(2)N-BZM7, and O(2)N-BZM9 had greater antigiardial activity (IC(50): 36, 14, and 17 M on trophoz …
Characterizing the Fused TvG6PD::6PGL Protein from the Protozoan Trichomonas vaginalis, and Effects of the NADP+ Molecule on Enzyme Stability.
Morales-Luna L, Hernández-Ochoa B, Ramírez-Nava EJ, Martínez-Rosas V, Ortiz-Ramírez P, Fernández-Rosario F, González-Valdez A, Cárdenas-Rodríguez N, Serrano-Posada H, Centeno-Leija S, Arreguin-Espinosa R, Cuevas-Cruz M, Ortega-Cuellar D, Pérez de la Cruz V, Rocha-Ramírez LM, Sierra-Palacios E, Castillo-Rodríguez RA, Vega-García V, Rufino-González Y, Marcial-Quino J, Gómez-Manzo S. Morales-Luna L, et al. Int J Mol Sci. 2020 Jul 8;21(14):4831. doi: 10.3390/ijms21144831. Int J Mol Sci. 2020. PMID: 32650494 Free PMC article.
Gene Cloning, Recombinant Expression, Characterization, and Molecular Modeling of the Glycolytic Enzyme Triosephosphate Isomerase from Fusarium oxysporum.
Hernández-Ochoa B, Gómez-Manzo S, Alcaraz-Carmona E, Serrano-Posada H, Centeno-Leija S, Arreguin-Espinosa R, Cuevas-Cruz M, González-Valdez A, Mendoza-Espinoza JA, Acosta Ramos M, Cortés-Maldonado L, Montiel-González AM, Pérez de la Cruz V, Rocha-Ramírez LM, Marcial-Quino J, Sierra-Palacios E. Hernández-Ochoa B, et al. Microorganisms. 2019 Dec 24;8(1):40. doi: 10.3390/microorganisms8010040. Microorganisms. 2019. PMID: 31878282 Free PMC article.
The recombinant protein named FoxTPI was purified (97% purity) showing a molecular mass of 27 kDa, with optimal activity at pH 8.0 and and temperature of 37 C. The values obtained for K(m) and V(max) using the substrate GAP were 0.47 0.1 mM, and 5331 mumol min(-1) mg(-1), …
The recombinant protein named FoxTPI was purified (97% purity) showing a molecular mass of 27 kDa, with optimal activity at pH 8.0 and and t …