Exome sequencing and analysis of 454,787 UK Biobank participants.
Backman JD, Li AH, Marcketta A, Sun D, Mbatchou J, Kessler MD, Benner C, Liu D, Locke AE, Balasubramanian S, Yadav A, Banerjee N, Gillies CE, Damask A, Liu S, Bai X, Hawes A, Maxwell E, Gurski L, Watanabe K, Kosmicki JA, Rajagopal V, Mighty J; Regeneron Genetics Center; DiscovEHR; Jones M, Mitnaul L, Stahl E, Coppola G, Jorgenson E, Habegger L, Salerno WJ, Shuldiner AR, Lotta LA, Overton JD, Cantor MN, Reid JG, Yancopoulos G, Kang HM, Marchini J, Baras A, Abecasis GR, Ferreira MAR.
Backman JD, et al.
Nature. 2021 Nov;599(7886):628-634. doi: 10.1038/s41586-021-04103-z. Epub 2021 Oct 18.
Nature. 2021.
PMID: 34662886
Free PMC article.
When these were tested for association with 3,994 health-related traits, we found 564 genes with trait associations at P 2.18 10(-11). Rare variant associations were enriched in loci from genome-wide association studies (GWAS), but most (91%) were independent of common var …
When these were tested for association with 3,994 health-related traits, we found 564 genes with trait associations at P 2.18 10(-11) …