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Page 1
Metformin in women with type 2 diabetes in pregnancy (MiTy): a multicentre, international, randomised, placebo-controlled trial.
Feig DS, Donovan LE, Zinman B, Sanchez JJ, Asztalos E, Ryan EA, Fantus IG, Hutton E, Armson AB, Lipscombe LL, Simmons D, Barrett JFR, Karanicolas PJ, Tobin S, McIntyre HD, Tian SY, Tomlinson G, Murphy KE; MiTy Collaborative Group. Feig DS, et al. Lancet Diabetes Endocrinol. 2020 Oct;8(10):834-844. doi: 10.1016/S2213-8587(20)30310-7. Lancet Diabetes Endocrinol. 2020. PMID: 32946820 Clinical Trial.
Insulin doses were adjusted aiming for identical glucose targets (fasting glucose <5.3 mmol/L [95 mg/dL], 2-h postprandial glucose <6.7 mmol/L [120 mg/dL]). ...We found no significant difference in the cord c-peptide between groups (673 pmol/L [435] in …
Insulin doses were adjusted aiming for identical glucose targets (fasting glucose <5.3 mmol/L [95 mg/dL], 2-h postprandial glucose …
L-type calcium channels: the low down.
Lipscombe D, Helton TD, Xu W. Lipscombe D, et al. J Neurophysiol. 2004 Nov;92(5):2633-41. doi: 10.1152/jn.00486.2004. J Neurophysiol. 2004. PMID: 15486420 Free article. Review.
L-type calcium channels couple membrane depolarization in neurons to numerous processes including gene expression, synaptic efficacy, and cell survival. ...Past literature contains several reports of low-voltage-activated neuronal L-type calcium channels that parall …
L-type calcium channels couple membrane depolarization in neurons to numerous processes including gene expression, synaptic efficacy, …
L-type calcium channels: highs and new lows.
Lipscombe D. Lipscombe D. Circ Res. 2002 May 17;90(9):933-5. doi: 10.1161/01.res.0000019740.52306.92. Circ Res. 2002. PMID: 12016257 No abstract available.
Neuronal L-type calcium channels open quickly and are inhibited slowly.
Helton TD, Xu W, Lipscombe D. Helton TD, et al. J Neurosci. 2005 Nov 2;25(44):10247-51. doi: 10.1523/JNEUROSCI.1089-05.2005. J Neurosci. 2005. PMID: 16267232 Free PMC article.
The effectiveness of these antagonists on L-type channels, however, varies with stimulus and channel subtype. Here, we study recombinant neuronal L-type calcium channels, CaV1.2 and CaV1.3. We show that these channels open with fast kinetics and carry substantial ca …
The effectiveness of these antagonists on L-type channels, however, varies with stimulus and channel subtype. Here, we study recombin …
Serum Urate Lowering with Allopurinol and Kidney Function in Type 1 Diabetes.
Doria A, Galecki AT, Spino C, Pop-Busui R, Cherney DZ, Lingvay I, Parsa A, Rossing P, Sigal RJ, Afkarian M, Aronson R, Caramori ML, Crandall JP, de Boer IH, Elliott TG, Goldfine AB, Haw JS, Hirsch IB, Karger AB, Maahs DM, McGill JB, Molitch ME, Perkins BA, Polsky S, Pragnell M, Robiner WN, Rosas SE, Senior P, Tuttle KR, Umpierrez GE, Wallia A, Weinstock RS, Wu C, Mauer M; PERL Study Group. Doria A, et al. N Engl J Med. 2020 Jun 25;382(26):2493-2503. doi: 10.1056/NEJMoa1916624. N Engl J Med. 2020. PMID: 32579810 Free PMC article. Clinical Trial.
Apoptosis inhibitor of macrophage and diabetic kidney disease.
Davis TME, Peters KE, Lipscombe R. Davis TME, et al. Cell Mol Immunol. 2019 May;16(5):521. doi: 10.1038/s41423-018-0088-x. Epub 2018 Jul 12. Cell Mol Immunol. 2019. PMID: 30002449 Free PMC article. No abstract available.
Neuronal Ca(V)1.3alpha(1) L-type channels activate at relatively hyperpolarized membrane potentials and are incompletely inhibited by dihydropyridines.
Xu W, Lipscombe D. Xu W, et al. J Neurosci. 2001 Aug 15;21(16):5944-51. doi: 10.1523/JNEUROSCI.21-16-05944.2001. J Neurosci. 2001. PMID: 11487617 Free PMC article.
L-type calcium channels regulate a diverse array of cellular functions within excitable cells. ...We now show that Ca(V)1.3alpha(1) L-type channels activate at membrane potentials approximately 25 mV more hyperpolarized, compared with Ca(V)1.2alpha(1). ...
L-type calcium channels regulate a diverse array of cellular functions within excitable cells. ...We now show that Ca(V)1.3alpha(1) …
The quality of diabetes care among cancer survivors: a retrospective cohort study.
Liang X, Etches J, Pinzaru B, Tu K, Jaakkimainen L, Lipscombe L. Liang X, et al. Diabet Med. 2021 Jun;38(6):e14538. doi: 10.1111/dme.14538. Epub 2021 Feb 21. Diabet Med. 2021. PMID: 33548062
Compared to controls, cancer people with diabetes were significantly less likely to receive ACE inhibitors or angiotensin receptor blockers (OR 0.75 [95% CI 0.64-0.89]), receive statin therapy if age 50-80 years (OR 0.79 [95% CI 0.68-0.92]) and achieve an LDL cholesterol level &l …
Compared to controls, cancer people with diabetes were significantly less likely to receive ACE inhibitors or angiotensin receptor blockers …
30 results