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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1958 1
1959 1
1964 3
1965 1
1967 1
1968 2
1970 2
1971 1
1973 2
1974 2
1975 4
1976 4
1977 7
1978 5
1979 8
1980 8
1981 9
1982 8
1983 19
1984 22
1985 14
1986 31
1987 30
1988 20
1989 44
1990 38
1991 48
1992 69
1993 41
1994 58
1995 76
1996 76
1997 102
1998 109
1999 116
2000 150
2001 148
2002 181
2003 199
2004 227
2005 305
2006 308
2007 340
2008 365
2009 396
2010 411
2011 430
2012 465
2013 526
2014 631
2015 660
2016 743
2017 726
2018 810
2019 931
2020 1086
2021 1211
2022 1317
2023 1329
2024 525

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13,830 results

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Page 1
Immunogenic chemotherapy in two mouse colon cancer models.
Taniura T, Iida Y, Kotani H, Ishitobi K, Tajima Y, Harada M. Taniura T, et al. Cancer Sci. 2020 Oct;111(10):3527-3539. doi: 10.1111/cas.14624. Epub 2020 Sep 1. Cancer Sci. 2020. PMID: 32816355 Free PMC article.
In the CT26 model, two injections of 5-FU/L-OHP and CP significantly suppressed the growth of subcutaneously established CT26 tumors compared with either 5-FU/L-OHP or CP, without a significant loss of body weight. ...The 5-FU/L-OHP treat …
In the CT26 model, two injections of 5-FU/L-OHP and CP significantly suppressed the growth of subcutaneously established CT26 …
N6-methyladenosine-mediated LDHA induction potentiates chemoresistance of colorectal cancer cells through metabolic reprogramming.
Zhang K, Zhang T, Yang Y, Tu W, Huang H, Wang Y, Chen Y, Pan K, Chen Z. Zhang K, et al. Theranostics. 2022 Jun 13;12(10):4802-4817. doi: 10.7150/thno.73746. eCollection 2022. Theranostics. 2022. PMID: 35832094 Free PMC article.
Background: Chemoresistance to 5-fluorouracil (5-FU) is a major barrier to influence the treatment efficiency of colorectal cancer (CRC) patients, while the precise molecular mechanisms underlying 5-FU resistance remain to be fully elucidated. ...Further, increased …
Background: Chemoresistance to 5-fluorouracil (5-FU) is a major barrier to influence the treatment efficiency of colorectal cancer (C …
Anti-inflammatory effect of L-cysteine (a semi-essential amino acid) on 5-FU-induced oral mucositis in hamsters.
Fonseca KM, Macda RodriguesCosta D, da Silva VF, de Carvalho JL, Oliveira AP, de Melo Sousa FB, Lopes ALF, da Silva Martins C, de Sousa Chaves L, Nicolau LAD, Cerqueira GS, Medeiros JVR. Fonseca KM, et al. Amino Acids. 2021 Sep;53(9):1415-1430. doi: 10.1007/s00726-021-03062-z. Epub 2021 Aug 19. Amino Acids. 2021. PMID: 34410507
In view of these properties, we investigate the effect of L-cys in oral mucositis induced by 5-FU in hamsters. The animals were divided into the following groups: saline 0.9%, mechanical trauma, 5-FU 60-40 mg/kg, L-cys 10/40 mg and NaHS 27 g/kg. 5-F …
In view of these properties, we investigate the effect of L-cys in oral mucositis induced by 5-FU in hamsters. The animals wer …
ADAM12-L confers acquired 5-fluorouracil resistance in breast cancer cells.
Wang X, Wang Y, Gu J, Zhou D, He Z, Wang X, Ferrone S. Wang X, et al. Sci Rep. 2017 Aug 29;7(1):9687. doi: 10.1038/s41598-017-10468-x. Sci Rep. 2017. PMID: 28852196 Free PMC article.
The overexpression of ADAM12-L in BC cells following 5-FU treatment results in the acquisition of resistance to 5-FU. ...These findings suggest that ADAM12-L mediates chemoresistance to 5-FU and 5-FU-induced recurrence of BC by enhancing …
The overexpression of ADAM12-L in BC cells following 5-FU treatment results in the acquisition of resistance to 5-FU. . …
L-arginine pretreatment reduces intestinal mucositis as induced by 5-FU in mice.
Leocádio PC, Antunes MM, Teixeira LG, Leonel AJ, Alvarez-Leite JI, Machado DC, Generoso SV, Cardoso VN, Correia MI. Leocádio PC, et al. Nutr Cancer. 2015;67(3):486-93. doi: 10.1080/01635581.2015.1004730. Epub 2015 Mar 24. Nutr Cancer. 2015. PMID: 25803482
The aim of this study was to evaluate the effect of pretreating with 2% L-arginine supplementation in water on mucositis as induced by 5-fluorouracil (5-FU; a single dose of 200 mg/kg body weight) in Swiss male mice. ...There was also an improvement in intestinal pe …
The aim of this study was to evaluate the effect of pretreating with 2% L-arginine supplementation in water on mucositis as induced b …
Effects of L-Arginine Supplementation on Leukogram, Inflammatory Bowel Infiltrates and Immunoglobulins with 5-FU Use in Rats.
Balmant BD, Araújo EON, Yabuki D, Novais AB, Genaro SC, Laposy CB, Goiozo PFI, Chacur MGM, Giuffrida R, Reis LSLS. Balmant BD, et al. Nutr Cancer. 2018 Feb-Mar;70(2):249-256. doi: 10.1080/01635581.2018.1424346. Epub 2018 Jan 18. Nutr Cancer. 2018. PMID: 29345500
Thirty-two Wistar rats were randomly distributed into 4 groups (8 rats/group): an untreated control group, and test groups receiving one dose of 5-FU (G(5-FU) group), one dose of 5-FU and 295 mg L-arginine/day (G(Arg295) group) or one dose of 5-FU …
Thirty-two Wistar rats were randomly distributed into 4 groups (8 rats/group): an untreated control group, and test groups receiving one dos …
Exosomes secreted by Fusobacterium nucleatum-infected colon cancer cells transmit resistance to oxaliplatin and 5-FU by delivering hsa_circ_0004085.
Hui B, Zhou C, Xu Y, Wang R, Dong Y, Zhou Y, Ding J, Zhang X, Xu J, Gu Y. Hui B, et al. J Nanobiotechnology. 2024 Feb 15;22(1):62. doi: 10.1186/s12951-024-02331-9. J Nanobiotechnology. 2024. PMID: 38360615 Free PMC article.
Fn infection promoted hsa_circ_0004085 formation by hnRNP L and packaged hsa_circ_0004085 into exosomes by hnRNP A1. Exosomes produced by Fn-infected CRC cells transferred hsa_circ_0004085 between cells and delivered oxaliplatin/5-FU resistance to recipient cells by …
Fn infection promoted hsa_circ_0004085 formation by hnRNP L and packaged hsa_circ_0004085 into exosomes by hnRNP A1. Exosomes produce …
Fabrication and Use of Poly(d,l-lactide-co-glycolide)-Based Formulations Designed for Modified Release of 5-Fluorouracil.
Leelakanok N, Geary S, Salem A. Leelakanok N, et al. J Pharm Sci. 2018 Feb;107(2):513-528. doi: 10.1016/j.xphs.2017.10.012. Epub 2017 Oct 16. J Pharm Sci. 2018. PMID: 29045885 Free PMC article. Review.
The biocompatible, biodegradable, and highly tunable synthetic polymer, poly(d,l-lactide-co-glycolide) (PLGA), is widely used as a vector for sustained drug delivery, however, issues such as insufficient loading and inappropriate burst release kinetics have dogged progress …
The biocompatible, biodegradable, and highly tunable synthetic polymer, poly(d,l-lactide-co-glycolide) (PLGA), is widely used as a ve …
l-arginine minimizes immunosuppression and prothrombin time and enhances the genotoxicity of 5-fluorouracil in rats.
de Andrade Bernal Fagiani M, Fluminhan A, de Azevedo Mello F, Yabuki D, Gonçalves GV, Tsujigushi LK, Pereira LG, da Silva KA, da Silva SBB, Santarem CL, Giozo PFI, de Souza Reis LSL. de Andrade Bernal Fagiani M, et al. Nutrition. 2019 Oct;66:94-100. doi: 10.1016/j.nut.2019.04.012. Epub 2019 May 23. Nutrition. 2019. PMID: 31252338
Supplementation with 50 mg/d of l-arginine decreased the weight loss generated by 5-FU in Wistar rats. Supplements with 50 or 100 mg of l-arginine did not interfere with 5-FU-generated jejunal inflammatory infiltrate....
Supplementation with 50 mg/d of l-arginine decreased the weight loss generated by 5-FU in Wistar rats. Supplements with 50 or …
The possible protective effect of L-arginine against 5-fluorouracil-induced nephrotoxicity in male albino rats.
Badawoud MH, Elshal EB, Zaki AI, Amin HA. Badawoud MH, et al. Folia Morphol (Warsz). 2017;76(4):608-619. doi: 10.5603/FM.a2017.0037. Epub 2017 May 29. Folia Morphol (Warsz). 2017. PMID: 28553862 Free article.
This work investigated the beneficial mechanism of L-arginine supplementation in 5-FU induced nephropathy. Eighty male Wistar rats were divided into four equal groups: control group; L-arginine group (378 mg/rat/day for 4 weeks); 5-FU group (189 mg/rat …
This work investigated the beneficial mechanism of L-arginine supplementation in 5-FU induced nephropathy. Eighty male Wistar …
13,830 results
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