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1953 1
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513 results

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Page 1
L-asparaginase production review: bioprocess design and biochemical characteristics.
Castro D, Marques ASC, Almeida MR, de Paiva GB, Bento HBS, Pedrolli DB, Freire MG, Tavares APM, Santos-Ebinuma VC. Castro D, et al. Appl Microbiol Biotechnol. 2021 Jun;105(11):4515-4534. doi: 10.1007/s00253-021-11359-y. Epub 2021 Jun 1. Appl Microbiol Biotechnol. 2021. PMID: 34059941 Review.
Biopharmaceuticals are mostly therapeutic recombinant proteins produced through biotechnological processes. In this context, L-asparaginase (L-asparagine amidohydrolase, L-ASNase (E.C. 3.5.1.1)) is a therapeutic enzyme that has been abundantly studied by rese …
Biopharmaceuticals are mostly therapeutic recombinant proteins produced through biotechnological processes. In this context, L-aspara …
Conflict of Interest Disclosures.
[No authors listed] [No authors listed] Global Spine J. 2023 May;13(2_suppl):568S-591S. doi: 10.1177/21925682231173597. Global Spine J. 2023. PMID: 37222100 Free PMC article. No abstract available.
Pediatric Moderate and Severe Traumatic Brain Injury: A Systematic Review of Clinical Practice Guideline Recommendations.
Ben Abdeljelil A, Freire GC, Yanchar N, Turgeon AF, Beno S, Bérubé M, Stang A, Stelfox T, Zemek R, Beaulieu E, Gagnon IJ, Gabbe B, Lauzier F, Labrosse M, Tardif PA, Deshommes T, Gnanvi J, Moore L. Ben Abdeljelil A, et al. J Neurotrauma. 2023 Nov;40(21-22):2270-2281. doi: 10.1089/neu.2023.0149. Epub 2023 Aug 16. J Neurotrauma. 2023. PMID: 37341019 Review.
Efficacy and Safety of a Recombinant Plant-Based Adjuvanted Covid-19 Vaccine.
Hager KJ, Pérez Marc G, Gobeil P, Diaz RS, Heizer G, Llapur C, Makarkov AI, Vasconcellos E, Pillet S, Riera F, Saxena P, Geller Wolff P, Bhutada K, Wallace G, Aazami H, Jones CE, Polack FP, Ferrara L, Atkins J, Boulay I, Dhaliwall J, Charland N, Couture MMJ, Jiang-Wright J, Landry N, Lapointe S, Lorin A, Mahmood A, Moulton LH, Pahmer E, Parent J, Séguin A, Tran L, Breuer T, Ceregido MA, Koutsoukos M, Roman F, Namba J, D'Aoust MA, Trepanier S, Kimura Y, Ward BJ; CoVLP Study Team. Hager KJ, et al. N Engl J Med. 2022 Jun 2;386(22):2084-2096. doi: 10.1056/NEJMoa2201300. Epub 2022 May 4. N Engl J Med. 2022. PMID: 35507508 Free PMC article. Clinical Trial.
A Patent Review on the Use of L-Asparaginase in the Treatment of Acute Lymphocytic Leukemia.
Freire DA, Lisboa Magalháes IC, Tramontina Florean EOP, Florindo Guedes MI. Freire DA, et al. Recent Adv Drug Deliv Formul. 2021;15(1):37-45. doi: 10.2174/1872211314666210301125843. Recent Adv Drug Deliv Formul. 2021. PMID: 33685385 Review.
L-asparaginase (L-asparagine amino hydrolase, E.C.3.5.1.1) is the most important chemotherapeutic drug used in treating Acute Lymphocytic Leukemia (ALL), decreasing blood asparagine rates causing apoptosis in tumor cells. ...This article reviewed published patents f …
L-asparaginase (L-asparagine amino hydrolase, E.C.3.5.1.1) is the most important chemotherapeutic drug used in treating Acute …
Rivaroxaban or Aspirin for Extended Treatment of Venous Thromboembolism.
Weitz JI, Lensing AWA, Prins MH, Bauersachs R, Beyer-Westendorf J, Bounameaux H, Brighton TA, Cohen AT, Davidson BL, Decousus H, Freitas MCS, Holberg G, Kakkar AK, Haskell L, van Bellen B, Pap AF, Berkowitz SD, Verhamme P, Wells PS, Prandoni P; EINSTEIN CHOICE Investigators. Weitz JI, et al. N Engl J Med. 2017 Mar 30;376(13):1211-1222. doi: 10.1056/NEJMoa1700518. Epub 2017 Mar 18. N Engl J Med. 2017. PMID: 28316279 Free article. Clinical Trial.
Recent Strategies and Applications for l-Asparaginase Confinement.
Nunes JCF, Cristóvão RO, Freire MG, Santos-Ebinuma VC, Faria JL, Silva CG, Tavares APM. Nunes JCF, et al. Molecules. 2020 Dec 10;25(24):5827. doi: 10.3390/molecules25245827. Molecules. 2020. PMID: 33321857 Free PMC article. Review.
l-asparaginase (ASNase, EC 3.5.1.1) is an aminohydrolase enzyme with important uses in the therapeutic/pharmaceutical and food industries. ...
l-asparaginase (ASNase, EC 3.5.1.1) is an aminohydrolase enzyme with important uses in the therapeutic/pharmaceutical and food indust …
Clinical Practice Guideline Recommendations in Pediatric Mild Traumatic Brain Injury: A Systematic Review.
Moore L, Ben Abdeljelil A, Tardif PA, Zemek R, Reed N, Yeates KO, Emery CA, Gagnon IJ, Yanchar N, Bérubé M, Dawson J, Berthelot S, Stang A, Beno S, Beaulieu E, Turgeon AF, Labrosse M, Lauzier F, Pike I, Macpherson A, Freire GC. Moore L, et al. Ann Emerg Med. 2024 Apr;83(4):327-339. doi: 10.1016/j.annemergmed.2023.11.012. Epub 2023 Dec 22. Ann Emerg Med. 2024. PMID: 38142375
Glutaminase-free L-asparaginase production by Leucosporidium muscorum isolated from Antarctic marine-sediment.
Freire RKB, Mendonça CMN, Ferraro RB, Moguel IS, Tonso A, Lourenço FR, Santos JHPM, Sette LD, Pessoa Junior A. Freire RKB, et al. Prep Biochem Biotechnol. 2021;51(3):277-288. doi: 10.1080/10826068.2020.1815053. Epub 2020 Sep 12. Prep Biochem Biotechnol. 2021. PMID: 32921254
Among 134 yeast strains isolated from marine-sediments in King George Island, Antarctica, nine were L-asparaginase producing yeasts and glutaminase-free. Leucosporidium muscorum CRM 1648 yielded the highest ASNase activity (490.41 U.L(-1)) and volumetric productivit …
Among 134 yeast strains isolated from marine-sediments in King George Island, Antarctica, nine were L-asparaginase producing yeasts a …
High-temperature Raman spectra of dipeptide alpha-L-aspartyl-L-alanine crystal.
Silva RF, Luz-Lima C, Freire PTC, Melo FEA, Pinheiro GS. Silva RF, et al. Spectrochim Acta A Mol Biomol Spectrosc. 2023 Sep 5;297:122746. doi: 10.1016/j.saa.2023.122746. Epub 2023 Apr 14. Spectrochim Acta A Mol Biomol Spectrosc. 2023. PMID: 37086536
Crystals of dipeptide alpha-L-aspartyl-L-alanine (alpha-Asp-Ala), C(7)H(12)N(2)O(5), were studied under high-temperature conditions through vibrational spectroscopy (IR and Raman) and thermal analysis (Differential Scanning Calorimetry - DSC). ...
Crystals of dipeptide alpha-L-aspartyl-L-alanine (alpha-Asp-Ala), C(7)H(12)N(2)O(5), were studied under high-temperature condi …
513 results