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Advances in colorectal cancer genomics and transcriptomics drive early detection and prevention.
Int J Biochem Cell Biol. 2021 Aug;137:106032. doi: 10.1016/j.biocel.2021.106032. Epub 2021 Jun 25.
Int J Biochem Cell Biol. 2021.
PMID: 34182137
Review.
Targeting the 'Undruggable' Driver Protein, KRAS, in Epithelial Cancers: Current Perspective.
Lam KK, Wong SH, Cheah PY.
Lam KK, et al.
Cells. 2023 Feb 15;12(4):631. doi: 10.3390/cells12040631.
Cells. 2023.
PMID: 36831298
Free PMC article.
Review.
Item in Clipboard
KRAS mutation-independent downregulation of MAPK/PI3K signaling in colorectal cancer.
Lam KK, Tang CL, Tan E, Wong SH, Cheah PY.
Lam KK, et al.
Mol Oncol. 2022 Mar;16(5):1171-1183. doi: 10.1002/1878-0261.13163. Epub 2022 Jan 1.
Mol Oncol. 2022.
PMID: 34919787
Free PMC article.
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The orphan nuclear receptor NR0B2 could be a novel susceptibility locus associated with microsatellite-stable, APC mutation-negative early-onset colorectal carcinomas with metabolic manifestation.
Lam KK, Sethi R, Tan G, Tomar S, Lo M, Loi C, Tang CL, Tan E, Lai PS, Cheah PY.
Lam KK, et al.
Genes Chromosomes Cancer. 2021 Feb;60(2):61-72. doi: 10.1002/gcc.22904. Epub 2020 Oct 29.
Genes Chromosomes Cancer. 2021.
PMID: 33094510
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KRAS-specific antibody binds to KRAS protein inside colorectal adenocarcinoma cells and inhibits its localization to the plasma membrane.
Lam KK, Low YS, Lo M, Wong M, Leong Tang C, Tan E, Chok AY, Seow-En I, Wong SH, Cheah PY.
Lam KK, et al.
Front Oncol. 2023 Mar 27;13:1036871. doi: 10.3389/fonc.2023.1036871. eCollection 2023.
Front Oncol. 2023.
PMID: 37051535
Free PMC article.
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Dioxonaphthoimidazoliums are Potent and Selective Rogue Stem Cell Clearing Agents with SOX2-Suppressing Properties.
Ho SH, Ali A, Ng YC, Lam KK, Wang S, Chan WK, Chin TM, Go ML.
Ho SH, et al.
ChemMedChem. 2016 Sep 6;11(17):1944-55. doi: 10.1002/cmdc.201600262. Epub 2016 Jul 22.
ChemMedChem. 2016.
PMID: 27444266
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