Objective: To prepare beta-cyclodextrin polymer (beta-CDP) beads using as a drug carrier and study the release behaviors of Berberine Hydrochlorrde (BH) in beta-CDP beads.
Methods: beta-CDP beads were synthesized by inverse emulsion polymerization. The inclusion complex between beta-CD and BH were investigated by phase solubility method. And the release of BH in vitro was studied by UV spectra.
Results: Inclusion compounds of beta-CD and BH with 1: 1 molar ratio were found under the condition of pH 1.4 and pH 7.4, with corresponding stability constants of 48.85 L/mol and 122.11 L/mol, respectively. Finally, the controlled release behavior of BH in polymer beads were studied and the release rate of BH kept almost constant after 24 h. Release rate of BH was higher at pH 1.4 than that at pH 7.4.
Conclusion: beta-CDP beads may be an ideal controlled drug release carrier.