SET/MYND Lysine Methyltransferases Regulate Gene Transcription and Protein Activity

Kristin Leinhart; Mark Brown

doi:10.3390/genes2010210

SET/MYND Lysine Methyltransferases Regulate Gene Transcription and Protein Activity

Genes (Basel). 2011 Feb 21;2(1):210-8. doi: 10.3390/genes2010210.

Authors

Kristin Leinhart¹, Mark Brown²

Affiliations

¹ Colorado State University, Fort Collins, CO 80523, USA. kjleinha@rams.colostate.edu.
² Colorado State University, Fort Collins, CO 80523, USA. m.brown@colostate.edu.

Abstract

The SET and MYND (SMYD) family of lysine methyltransferases is defined by a SET domain that is split into two segments by a MYND domain, followed by a cysteine-rich post-SET domain. While members of the SMYD family are important in the SET-mediated regulation of gene transcription, pathological consequences have also been associated with aberrant expression of SMYD proteins. The last decade has witnessed a rapid increase in the studies and corresponding understanding of these highly impactful enzymes. Herein, we review the current body of knowledge related to the SMYD family of lysine methyltransferases and their role in transcriptional regulation, epigenetics, and tumorigenesis.