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Platelets, Bacterial Adhesins and the Pneumococcus.
Jahn K, Kohler TP, Swiatek LS, Wiebe S, Hammerschmidt S. Jahn K, et al. Cells. 2022 Mar 25;11(7):1121. doi: 10.3390/cells11071121. Cells. 2022. PMID: 35406684 Free PMC article. Review.
α-hemolysin of Staphylococcus aureus impairs thrombus formation.
Jahn K, Handtke S, Palankar R, Kohler TP, Wesche J, Wolff M, Bayer J, Wolz C, Greinacher A, Hammerschmidt S. Jahn K, et al. J Thromb Haemost. 2022 Jun;20(6):1464-1475. doi: 10.1111/jth.15703. Epub 2022 Mar 27. J Thromb Haemost. 2022. PMID: 35303391 Free article.
Polyvalent Immunoglobulin Preparations Inhibit Pneumolysin-Induced Platelet Destruction.
Wiebe F, Handtke S, Wesche J, Schnarre A, Palankar R, Wolff M, Jahn K, Voß F, Weißmüller S, Schüttrumpf J, Greinacher A, Hammerschmidt S. Wiebe F, et al. Among authors: jahn k. Thromb Haemost. 2022 Jul;122(7):1147-1158. doi: 10.1055/a-1723-1880. Epub 2021 Dec 16. Thromb Haemost. 2022. PMID: 34918314 Free PMC article.
Pneumolysin induces platelet destruction, not platelet activation, which can be prevented by immunoglobulin preparations in vitro.
Jahn K, Handtke S, Palankar R, Weißmüller S, Nouailles G, Kohler TP, Wesche J, Rohde M, Heinz C, Aschenbrenner AF, Wolff M, Schüttrumpf J, Witzenrath M, Hammerschmidt S, Greinacher A. Jahn K, et al. Blood Adv. 2020 Dec 22;4(24):6315-6326. doi: 10.1182/bloodadvances.2020002372. Blood Adv. 2020. PMID: 33351126 Free PMC article. Clinical Trial.