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Page 1
The flavonoid monoHER promotes the adaption to oxidative stress during the onset of NAFLD.
Biochem Biophys Res Commun. 2015 Jan 2;456(1):179-82. doi: 10.1016/j.bbrc.2014.11.055. Epub 2014 Nov 22.
Biochem Biophys Res Commun. 2015.
PMID: 25462563
Withaferin A induces heme oxygenase (HO-1) expression in endothelial cells via activation of the Keap1/Nrf2 pathway.
Heyninck K, Sabbe L, Chirumamilla CS, Szarc Vel Szic K, Vander Veken P, Lemmens KJA, Lahtela-Kakkonen M, Naulaerts S, Op de Beeck K, Laukens K, Van Camp G, Weseler AR, Bast A, Haenen GRMM, Haegeman G, Vanden Berghe W.
Heyninck K, et al. Among authors: lemmens kja.
Biochem Pharmacol. 2016 Jun 1;109:48-61. doi: 10.1016/j.bcp.2016.03.026. Epub 2016 Apr 1.
Biochem Pharmacol. 2016.
PMID: 27045103
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Rutin protects against H2O2-triggered impaired relaxation of placental arterioles and induces Nrf2-mediated adaptation in Human Umbilical Vein Endothelial Cells exposed to oxidative stress.
Sthijns MMJPE, Schiffers PM, Janssen GM, Lemmens KJA, Ides B, Vangrieken P, Bouwman FG, Mariman EC, Pader I, Arnér ESJ, Johansson K, Bast A, Haenen GRMM.
Sthijns MMJPE, et al. Among authors: lemmens kja.
Biochim Biophys Acta Gen Subj. 2017 May;1861(5 Pt A):1177-1189. doi: 10.1016/j.bbagen.2017.03.004. Epub 2017 Mar 7.
Biochim Biophys Acta Gen Subj. 2017.
PMID: 28286015
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The flavonoid 7-mono-O-(β-hydroxyethyl)-rutoside is able to protect endothelial cells by a direct antioxidant effect.
Lemmens KJ, van de Wier B, Vaes N, Ghosh M, van Zandvoort MA, van der Vijgh WJ, Bast A, Haenen GR.
Lemmens KJ, et al.
Toxicol In Vitro. 2014 Jun;28(4):538-43. doi: 10.1016/j.tiv.2013.12.019. Epub 2014 Jan 8.
Toxicol In Vitro. 2014.
PMID: 24412621
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The minor structural difference between the antioxidants quercetin and 4'O-methylquercetin has a major impact on their selective thiol toxicity.
Lemmens KJ, Vrolijk MF, Bouwman FG, van der Vijgh WJ, Bast A, Haenen GR.
Lemmens KJ, et al.
Int J Mol Sci. 2014 Apr 30;15(5):7475-84. doi: 10.3390/ijms15057475.
Int J Mol Sci. 2014.
PMID: 24786288
Free PMC article.
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The contribution of the major metabolite 4'-O-methylmonoHER to the antioxidant activity of the flavonoid monoHER.
Lemmens KJ, Herst PM, Housmans BA, Moalin M, van der Vijgh WJ, Bast A, Haenen GR.
Lemmens KJ, et al.
Chem Biol Interact. 2015 Sep 5;239:146-52. doi: 10.1016/j.cbi.2015.07.004. Epub 2015 Jul 8.
Chem Biol Interact. 2015.
PMID: 26163455
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