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Blood-brain barrier penetration of non-replicating SARS-CoV-2 and S1 variants of concern induce neuroinflammation which is accentuated in a mouse model of Alzheimer's disease.
Erickson MA, Logsdon AF, Rhea EM, Hansen KM, Holden SJ, Banks WA, Smith JL, German C, Farr SA, Morley JE, Weaver RR, Hirsch AJ, Kovac A, Kontsekova E, Baumann KK, Omer MA, Raber J. Erickson MA, et al. Among authors: baumann kk. Brain Behav Immun. 2023 Mar;109:251-268. doi: 10.1016/j.bbi.2023.01.010. Epub 2023 Jan 20. Brain Behav Immun. 2023. PMID: 36682515 Free PMC article.
The S1 protein of SARS-CoV-2 crosses the blood-brain barrier in mice.
Rhea EM, Logsdon AF, Hansen KM, Williams LM, Reed MJ, Baumann KK, Holden SJ, Raber J, Banks WA, Erickson MA. Rhea EM, et al. Among authors: baumann kk. Nat Neurosci. 2021 Mar;24(3):368-378. doi: 10.1038/s41593-020-00771-8. Epub 2020 Dec 16. Nat Neurosci. 2021. PMID: 33328624 Free PMC article.
Transport of the Proinflammatory Chemokines C-C Motif Chemokine Ligand 2 (MCP-1) and C-C Motif Chemokine Ligand 5 (RANTES) across the Intact Mouse Blood-Brain Barrier Is Inhibited by Heparin and Eprodisate and Increased with Systemic Inflammation.
Quaranta DV, Weaver RR, Baumann KK, Fujimoto T, Williams LM, Kim HC, Logsdon AF, Omer M, Reed MJ, Banks WA, Erickson MA. Quaranta DV, et al. Among authors: baumann kk. J Pharmacol Exp Ther. 2023 Jan;384(1):205-223. doi: 10.1124/jpet.122.001380. Epub 2022 Oct 30. J Pharmacol Exp Ther. 2023. PMID: 36310035 Free PMC article.