PDMS Bonding Technologies for Microfluidic Applications: A Review

Biosensors (Basel). 2021 Aug 23;11(8):292. doi: 10.3390/bios11080292.

Abstract

This review summarizes and compares the available surface treatment and bonding techniques (e.g., corona triggered surface activation, oxygen plasma surface activation, chemical gluing, and mixed techniques) and quality/bond-strength testing methods (e.g., pulling test, shear test, peel test, leakage test) for bonding PDMS (polydimethylsiloxane) with other materials, such as PDMS, glass, silicon, PET (polyethylene terephthalate), PI (polyimide), PMMA (poly(methyl methacrylate)), PVC (polyvinyl chloride), PC (polycarbonate), COC (cyclic olefin copolymer), PS (polystyrene) and PEN (polyethylene naphthalate). The optimized process parameters for the best achievable bond strengths are collected for each substrate, and the advantages and disadvantages of each method are discussed in detail.

Keywords: PDMS; bond strength; bonding technologies; polymers.

Publication types

  • Review

MeSH terms

  • Cycloparaffins
  • Dimethylpolysiloxanes
  • Microfluidic Analytical Techniques*
  • Microfluidics
  • Polycarboxylate Cement
  • Polymers
  • Polymethyl Methacrylate
  • Silicon
  • Surface Properties
  • Temperature

Substances

  • Cycloparaffins
  • Dimethylpolysiloxanes
  • Polycarboxylate Cement
  • Polymers
  • polycarbonate
  • baysilon
  • Polymethyl Methacrylate
  • Silicon