Newly synthesized naphthalene diimide carrying two β-cyclodextrins (NDI-β-CyDs) showed improved specificity for the parallel G-quadruplex structure alongside the hybrid G-quadruplex structure. Specifically, the highest binding affinity of NDI-β-CyDs for the telomere RNA G-quadruplex was observed. The binding simulation indicated that β-cyclodextrins might be available for loop nucleobase inclusion under its complex.
Keywords: DNA; RNA; apyromidinic sites; c-kit; c-myc; naphthalene diimide; nucleobase inclusion; parallel G-quadruplex; telomere RNA; β-cyclodextrins (β-CyDs).