Single Probiotic versus Multiple Probiotics - A Debate On Current Scenario for Alleviating Health Benefits

Siva K Korada; Nagendra S Yarla; Vijayendra Mishra; Mohamed A Daim; Bechan Sharma; Ashraf Gm; Reggi R; Palmery M; Ilaria Peluso; Mohammad A Kamal

doi:10.2174/1381612824666181012124136

Single Probiotic versus Multiple Probiotics - A Debate On Current Scenario for Alleviating Health Benefits

Curr Pharm Des. 2018;24(35):4150-4153. doi: 10.2174/1381612824666181012124136.

Authors

Siva K Korada¹, Nagendra S Yarla², Vijayendra Mishra¹, Mohamed A Daim^{3

4}, Bechan Sharma⁵, Ashraf Gm⁶, Reggi R⁷, Palmery M⁷, Ilaria Peluso⁸, Mohammad A Kamal^{6

9

10}

Affiliations

¹ National Institute of Food Technology Entrepreneurship and Management (NIFTEM), Sonepat, Haryana, India.
² Department of Animal Biology, School of Life Sciences, University of Hyderabad, Gachibowli, Hyderabad 500 046, Telagana, India.
³ Pharmacology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt.
⁴ Department of Ophthalmology and Micro-Technology, Yokohama City University, Yokohama, Japan.
⁵ Department of Biochemistry, University of Allahabad, Allahabad, India.
⁶ King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
⁷ Department of Physiology and Pharmacology "V. Erspamer", "Sapienza" University of Rome, Italy.
⁸ Research Center for Food and Nutrition, Council for Agricultural Research and Economics, (CREA-AN), Rome, Italy.
⁹ Enzymoics, 7 Peterlee Place, Hebersham, NSW 2770, Australia.
¹⁰ Novel Global Community Educational Foundation, Australia.

PMID: 30317991
DOI: 10.2174/1381612824666181012124136

Abstract

Strain, dose, duration, validated clinical trial studies and scientific substantiation of health claims are needed in order to define a successful probiotic. In particular, the potency of probiotic differs from strain to strain. In this view, we aimed to know whether the single strain or multi-strain construct is more beneficial. We found that the studies were still under debate and mechanisms remain sometimes unclear. No conclusion can be made based on the strain experimentation. Safety data and significant statistical results for efficacy via well-controlled clinical trials are needed.

Keywords: Probiotics; gut microbiota; health benefits; multiple probiotics; safety recommendation; single strain..

Publication types

Review

MeSH terms

Colitis / drug therapy*
Humans
Inflammatory Bowel Diseases / drug therapy*
Probiotics / therapeutic use*